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Data sheet of Mouse Monoclonal to TPX2
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to TPX2
| Brand: | Exbio |
| Product no.: | 11-818-C100 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to TPX2 |
| Antigen: | TPX2 |
| Clonality: | Monoclonal |
| Clone: | TPX2-01 |
| Isotype: | IgG1 |
| Immunogen: | Human TPX2 |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody TPX2-01 recognizes the epitope EPFVPKKEKKS (aa 636-646 in human) of TPX2, a microtubule-associated critical regulator of mitosis, which is overexpressed in many types of tumors and is a marker of worse prognosis in various cancers. |
| Categories: | Cytoskeleton: Tubulin System (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | TPX2 is a microtubule-associated protein, which is a critical regulator of mitosis. At the beginning of mitosis, TPX2 is released and plays a significant role in mitotic spindle formation and subsequent proper segregation of chromosomes during cell division. After completion of mitosis the TPX2 protein disappears, but has also role in DNA damage response. Its overexpression has been demonstrated in many types of carcinomas. TPX2 belongs to the markers of worse tumor prognosis. On the other hand, down-regulation of TPX2 can inhibit cancer cell proliferation, migration and invasion. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified from hybridoma culture supernatant by protein-A affinity chromatography. |
| General references: | *Tomii C, Inokuchi M, Takagi Y, Ishikawa T, Otsuki S, Uetake H, Kojima K, Kawano T: TPX2 expression is associated with poor survival in gastric cancer. World J Surg Oncol. 2017 Jan 9;15(1):14. doi: 10.1186/s12957-016-1095-y, Wang J, Liu Z, Dou C, Han S, Li C, Tu K, Yang W: miR-491 inhibits the proliferation, invasion and migration of hepatocellular carcinoma cell via down-regulating TPX2 expression. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Apr;32(4):512-7., *Zhang H, Zhang T, You Z, Zhang Y: Positive Surgical Margin, HPV Persistence, and Expression of Both TPX2 and PD-L1 Are Associated with Persistence/Recurrence of Cervical Intraepithelial Neoplasia after Cervical Conization. PLoS One. 2015 Dec 1;10(12):e0142868. , *Miwa T, Kokuryo T, Yokoyama Y, Yamaguchi J, Nagino M: Therapeutic potential of targeting protein for Xklp2 silencing for pancreatic cancer. Cancer Med. 2015 Jul;4(7):1091-100 |
| Related products: | - Mouse Monoclonal to TRIM / TRAT1 - Mouse Monoclonal to Transferrin - Mouse Monoclonal to Transferrin (porcine) |
| Shipping condition: | Room temperature |