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Data sheet of Rat Monoclonal to CD132
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Canine (Dog) |
| Clonality | Monoclonal |
More info about Rat Monoclonal to CD132
| Brand: | Exbio |
| Product no.: | 11-194-C100 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Rat Monoclonal to CD132 |
| Antigen: | CD132 |
| Clonality: | Monoclonal |
| Clone: | TUGh4 |
| Isotype: | IgG2b |
| Immunogen: | Human CD132-transfected cell line |
| Format: | purified |
| Specificity: | The rat monoclonal antibody TUGh4 recognizes CD132 (the common gamma chain), a 65-70 kDa type I transmembrane glycoprotein broadly expressed by most leukocytes._x000D_ _x000D_ HLDA VI; WS Code C-89 |
| Categories: | CD Antigens & MHC (Veterinary), CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD132 / common gamma chain is an essential component of receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, and it is critical for development of the immune system. Its mutation causes X-linked severe combined immunodeficiency disease (XSCID). CD132 is expressed on lymphocytes, NK cells, monocytes, and granulocytes. Through its cytoplasmic part which containsfour tyrosines and an SH2 domain, CD132 transcuces signal to downstream JAK/STAT pathway. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified from hybridoma culture supernatant by protein-G affinity chromatography. |
| Product specific references: | *Itano M, Tsuchiya S, Morita S, Fujie H, Ishii N, Yanagisawa T, Ohashi Y, Minegishi M, Sugamura K, Konno T: IL-2 receptor gamma chain expression on CD34 positive hematopoietic progenitor cells from bone marrow and cord blood. Tohoku J Exp Med. 1996 Apr;178(4):389-98., *Marino JH, Tan C, Taylor AA, Bentley C, Van De Wiele CJ, Ranne R, Paliotta M, Broughan TA, Teague TK: Differential IL-7 responses in developing human thymocytes. Hum Immunol. 2010 Apr;71(4):329-33., *Fiorito S, Magrini L, Adrey J, Mailhé D, Brouty-Boyé D: Inflammatory status and cartilage regenerative potential of synovial fibroblasts from patients with osteoarthritis and chondropathy. Rheumatology (Oxford). 2005 Feb;44(2):164-71., *Amu S, Brisslert M: Phenotype and function of CD25-expressing B lymphocytes isolated from human umbilical cord blood. Clin Dev Immunol. 2011;2011:481948., *Brisslert M, Bokarewa M, Larsson P, Wing K, Collins LV, Tarkowski A: Phenotypic and functional characterization of human CD25+ B cells. Immunology. 2006 Apr;117(4):548-57., *Corrigall VM, Arastu M, Khan S, Shah C, Fife M, Smeets T, Tak PP, Panayi GS: Functional IL-2 receptor beta (CD122) and gamma (CD132) chains are expressed by fibroblast-like synoviocytes: activation by IL-2 stimulates monocyte chemoattractant protein-1 production. J Immunol. 2001 Mar 15;166(6):4141-7. |
| Related products: | - Rat Monoclonal to CD197 / CCR7 (mouse) - Rat Monoclonal to CD18 (mouse) / Integrin beta2 subunit - Rat Monoclonal to CD19 (mouse) |
| Shipping condition: | Room temperature |