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Data sheet of Mouse Monoclonal to CD172b / SIRP beta
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD172b / SIRP beta
| Brand: | Exbio |
| Product no.: | 11-134-C100 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD172b / SIRP beta |
| Antigen: | CD172b / SIRP beta |
| Clonality: | Monoclonal |
| Clone: | B4B6 |
| Isotype: | IgG1 |
| Immunogen: | NIH-3T3 cells transfected with human CD172b |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody B4B6 recognizes CD172b, an approximately 50 kDa transmembrane glycoprotein expressed on myeloid cells._x000D_ _x000D_ HLDA 8 |
| Categories: | CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD172b, the signal-regulatory protein beta (SIRP beta) is a disulfide-linked homodimer expressed on myeloid cells including monocytes and dendritic cells. Similarly to CD172a, it serves as a negative regulator of tyrosine kinase-coupled signaling processes. Unlike CD172a, the CD172b protein does not possess the cytoplasmic domain, but instead its transmembrane domain can interact with another transmembrane protein DAP-12, which contains ITAM sequences in its intracellular domain and links CD172b to the downstream signaling molecules. The result is e.g. regulation of neutrophil transepithelial migration. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Schäkel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M: CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF. J Exp Med. 2013 Jun 3;210(6):1251-63. |
| Related products: | - Mouse Monoclonal to CD18 (bovine) - Mouse Monoclonal to CD173 - Mouse Monoclonal to CD178 / Fas-L |
| Shipping condition: | Room temperature |