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Mouse Monoclonal antibody to human XPG (Xeroderma pigmentosum group G)
PTGX-XPG-1B5
New product
Data sheet of Mouse Monoclonal antibody to human XPG (Xeroderma pigmentosum group G)
| Brand | ProteoGenix |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
| Host species | Mouse |
| Applications | E, WB, IC, IP |
More info about Mouse Monoclonal antibody to human XPG (Xeroderma pigmentosum group G)
| Brand: | ProteoGenix |
| Proteogenix reference: | PTGX-XPG-1B5 |
| Product type: | Primary antibodies |
| Clonality: | Monoclonal |
| Product name: | Mouse Monoclonal antibody to human XPG (Xeroderma pigmentosum group G) |
| Host species: | Mouse |
| Target species: | Human |
| Reactivity: | Human |
| Applications: | E, WB, IC, IP |
| Size: | 100µl |
| Clone name: | 1XPGâ€1B5 |
| Uniprot: | #N/A |
| Immunogen: | Synthetic peptide (KKRRKLRRARGRKRKT) corresponding to aa 1171-1186 of human XPG. |
| Specificity: | human XPG. |
| Dilution: | 1/500-1/5000 |
| Alternative names: | COFS 3 antibody, COFS3 antibody, DNA excision repair protein ERCC 5 antibody, DNA excision repair protein ERCC-5 antibody, DNA excision repair protein ERCC5 antibody, DNA repair protein complementing XP G cells antibody, DNA repair protein complementing XP-G cells antibody, DNA repair protein complementing XPG cells antibody, ERCC 5 antibody, ERCC5 antibody, ERCC5_HUMAN antibody, ERCM 2 antibody, ERCM2 antibody, Excision repair cross complementation group 5 antibody, Excision Repair Cross Complementing Rodent Repair Deficiency antibody, Excision repair cross complementing rodent repair deficiency complementation group 5 antibody, Excision repair protein antibody, OTTHUMP00000064902 antibody, UVDR antibody, Xeroderma Pigmentosum Complementation Group G antibody, Xeroderma pigmentosum complementation group G protein antibody, Xeroderma pigmentosum group G complementing protein antibody, Xeroderma pigmentosum group G-complementing protein antibody, XPG antibody, XPG complementing protein antibody, XPGC antibody |
| Isotype: | IgG1, k |
| Form: | liquid/frozen |
| Spec:conjugate/tag/label: | Unconjugated |
| Research area: | DNA Damage and Repair, Epigenetics & Nuclear Signalling |
| Background information: | Mouse monoclonal antibody to human XPG, clone 1XPGâ€1B5. XPG or ERCC5 is a single stranded structure-specific DNA endonuclease involved in DNA excision repair following UV-induced damage. Makes the 3’ incision in DNA nucleotide excision repair. It also acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. The protein may also be involved in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations cause xeroderma pigmentosum complementation group G (XP-G) ; also known as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and high predisposition for developing cancers on areas exposed to sunlight etc. Patients also develop Cockayne syndrome, including microcephaly, mental retardation, ataxia etc. |
| Publications: | 1. Riedl T, Hanaoka F, Egly JM. The comings and goings of nucleotide excision repair factors on damaged DNA. EMBO J. 2003 Oct 1;22(19):5293-303. 2. Le May et al., XPG and XPF Endonucleases Trigger Chromatin Looping and DNA Demethylation for Accurate Expression of Activated Genes, Molecular Cell (2012), http://dx.doi.org/10.1016/j.molcel.2012.05.050 |
| Storage: | Store at -20°C. Aliquot to avoid repeated freezing and thawing. |
| Delivery lead time in business days in europe: | 2-3 |
| Delivery conditions: | Dry Ice |
| Related products: | - Bcl-2 Monoclonal Antibody - HSP70 Monoclonal Antibody - Galectin-3 Monoclonal Antibody |