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Data sheet of Mouse Monoclonal antibody to human SMRT
| Brand | ProteoGenix |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
| Host species | Mouse |
| Applications | E, WB, IC |
More info about Mouse Monoclonal antibody to human SMRT
| Brand: | ProteoGenix |
| Proteogenix reference: | PTGX-SMRT-1E7 |
| Product type: | Primary antibodies |
| Clonality: | Monoclonal |
| Product name: | Mouse Monoclonal antibody to human SMRT |
| Host species: | Mouse |
| Target species: | Human |
| Reactivity: | Human |
| Applications: | E, WB, IC |
| Size: | 100µl |
| Clone name: | 1SMâ€1E7 |
| Uniprot: | #N/A |
| Immunogen: | recombinant human SMRT protein (aa 982-1695). |
| Specificity: | human SMRT protein. Epitope between aa 982 and 1695 |
| Dilution: | 1/500-1/5000 |
| Alternative names: | CTG 26 antibody, CTG repeat protein 26 antibody, CTG26 antibody, N CoR2 antibody, N-CoR2 antibody, NCoR 2 antibody, Ncor2 antibody, NCOR2_HUMAN antibody, Nuclear Receptor Co-Repressor 2 antibody, Nuclear receptor corepressor 2 antibody, retinoic-acid-receptor-associated corepressor antibody, Silencing Mediator for Retanoid and Thyroid Hormone Receptors antibody, Silencing mediator of retinoic acid and thyroid hormone receptor antibody, SMAP 270 antibody, SMAP270 antibody, SMRT antibody, SMRTE antibody, SMRTE tau antibody, T3 receptor associating factor antibody, T3 receptor-associating factor antibody, Thyroid retinoic acid receptor associated corepressor antibody, Thyroid- antibody, TNRC 14 antibody, TNRC14 antibody, TRAC 1 antibody, TRAC antibody, TRAC1 antibody, Anti-NCOR2 antibody |
| Isotype: | IgG2a, k |
| Form: | liquid/frozen |
| Spec:conjugate/tag/label: | Unconjugated |
| Research area: | Epigenetics & Nuclear Signalling |
| Background information: | Mouse monoclonal anti-SMRT antibody, clone 1SM-1E7 recognize human SMRT. SMRT/NCOR2 is a nuclear receptor that mediates the transcriptional repression, thus facilitates transcriptional silencing. It is also known as the silencing mediator of retinoic acid & thyroid hormone receptor protein. This repressor has been investigated as a biomarker to predict medical care efficacy in estrogen receptor positive breast cancer patients. It is also an element of the N-Cor repressor, a multi-subunit complex composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. NCOR2/SMRT acts as a platform protein, helping the recruitment of histone deacetylases to the DNA promoters bound through its interacting transcription factors. |
| Publications: | 1: Rajendran P, Delage B, Dashwood WM, Yu TW, Wuth B, Williams DE, Ho E, Dashwood RH. Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer. 2011 May 30;10:68. doi: 10.1186/1476-4598-10-68. PubMed PMID: 21624135; PubMed Central PMCID: PMC3127849. |
| Storage: | Store at -20°C. Aliquot to avoid repeated freezing and thawing. |
| Delivery lead time in business days in europe: | 2-3 |
| Delivery conditions: | Dry Ice |
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