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Data sheet of Mouse Monoclonal to Ubinuclein 1
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Other species Not tested |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Ubinuclein 1
| Brand: | Exbio |
| Product no.: | 11-565-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Ubinuclein 1 |
| Antigen: | Ubinuclein 1 |
| Clonality: | Monoclonal |
| Clone: | UBN1-02 |
| Isotype: | IgG |
| Immunogen: | Recombinant protein corresponding to amino acids 1-190 of ubinuclein 1. |
| Format: | purified |
| Specificity: | The antibody UBN1-02 recognizes N-terminal part of ubinuclein 1 (UBN1), a widely expressed nuclear and adhesion complex protein. Western blotting analysis reveals UBN1 as a 165 kDa band. |
| Categories: | Transcription Regulation & Nuclear Proteins (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| General references: | *Aho S, Buisson M, Pajunen T, Ryoo YW, Giot JF, Gruffat H, Sergeant A, Uitto J: Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. J Cell Biol. 2000 Mar 20;148(6):1165-76., *Aho S, Lupo J, Coly PA, Sabine A, Castellazzi M, Morand P, Sergeant A, Manet E, Boyer V, Gruffat H: Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NaCos). Biol Cell. 2008 Sep 30., *Banumathy G, Somaiah N, Zhang R, Tang Y, Hoffmann J, Andrake M, Ceulemans H, Schultz D, Marmorstein R, Adams PD: Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol Cell Biol. 2009 Feb;29(3):758-70. |
| Related products: | - Mouse Monoclonal to ZAP-70 - Mouse Monoclonal to VCP - Mouse Monoclonal to Vimentin |
| Shipping condition: | Room temperature |