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Data sheet of Rabbit Polyclonal to TCF4 / TF7L2
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Mouse |
| Clonality | Polyclonal |
| Host species | Rabbit |
| Applications | IP, WB, IHC(P), ICC |
More info about Rabbit Polyclonal to TCF4 / TF7L2
| Brand: | Exbio |
| Product no.: | 11-513-C025 |
| Product name: | Rabbit Polyclonal to TCF4 / TF7L2 |
| Antigen: | TCF4 / TF7L2 |
| Clonality: | Polyclonal |
| Clone: | Polyclonal |
| Immunogen: | Bacterially expressed full-length human TCF4 |
| Format: | purified |
| Specificity: | Tha polyclonal antibody reacts with TCF4. TCF4 (transcription factor 7-like 2; 66 kDa) serves as a transcriptional activator affecting e.g. cell cycle and terminal cell differentiation. |
| Categories: | Transcription Regulation & Nuclear Proteins (Human), Transcription Regulation & Nuclear Proteins |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | TCF4 (T cell factor 4; also known as TF7L2) serves as transcriptional activator affecting e.g. cell cycle and terminal cell differentiation. In the absence of Wnt signals, TCF4 interacts with TLE/Groucho corepressor, supressing the transcription of TCF4 target genes. Wnt signaling leads to stabilisation and accumulation of beta-catenin, which binds TCF4 N-terminus, whereas TCF4 C-terminal HMG-box domains interact with DNA. Cell death-associated Daxx protein or plakoglobin belong to negative regulators of TCF4-mediated transcription, on the other hand, there is a positive feedback loop of beta-catenin-TCF4 pathway comprising the p300 coactivator. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified from rabbit serum by protein-A affinity chromatography. |
| Product specific references: | *Lukas J, Mazna P, Valenta T, Doubravska L, Pospichalova V, Vojtechova M, Fafilek B, Ivanek R, Plachy J, Novak J, Korinek V: Dazap2 modulates transcription driven by the Wnt effector TCF-4. Nucleic Acids Res. 2009 Mar 20. [Epub ahead of print] , *Valenta T, Lukas J, Doubravska L, Fafilek B, Korinek V.: HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. EMBO J. 2006 Jun 7;25(11):2326-37. |
| General references: | *Tzeng SL, Cheng YW, Li CH, Lin YS, Hsu HC, Kang JJ: Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells. J Biol Chem. 2006 Jun 2;281(22):15405-11., *Valenta T, Lukas J, Korinek V.: HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. Nucleic Acids Res. 2003 May 1;31(9):2369-80., *Raurell I, Castaño J, Francà C, GarcÃa de Herreros A, Duñach M.: Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of beta-catenin/Tcf-4-dependent transcription. J Biol Chem. 2006 Jan 20;281(3):1401-11. |
| Shipping condition: | Room temperature |