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Data sheet of Mouse Monoclonal to STAT1 (Phospho-Ser727)
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Other not tested, Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to STAT1 (Phospho-Ser727)
| Brand: | Exbio |
| Product no.: | 11-372-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to STAT1 (Phospho-Ser727) |
| Antigen: | STAT1 (Phospho-Ser727) |
| Clonality: | Monoclonal |
| Clone: | PSM1 |
| Isotype: | IgG1 |
| Immunogen: | STAT1 peptide sequence 721-733 (Ser727 phosphorylated). |
| Format: | purified |
| Specificity: | The antibody PSM1 recognizes transcriptional factor STAT1 (91 kDa) activated by phosphorylation at Ser727. |
| Categories: | Cytokine Signaling (Human), Transcription Regulation & Nuclear Proteins (Human), Transcription Regulation & Nuclear Proteins |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation. However, the both modifications are important for its maximal transcriptional activity. On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Kovarik J, Boudny V, Kocak I, Lauerova L, Fait V, Vagundova M: Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation. Int J Mol Med. 2003 Sep;12(3):335-40., *Boudny V, Kocak I, Lauerova L, Kovarik J: Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients. Folia Biol (Praha). 2003;49(4):142-6. _x000D_ |
| General references: | *Soond SM, Townsend PA, Barry SP, Knight RA, Latchman DS, Stephanou A: ERK and the E3 ubiquitin ligase beta TRCP targets STAT1 for degradation. J Biol Chem. 2008 Mar 31_x000D_ _x000D_ , *Bromberg J, Darnell JE Jr: The role of STATs in transcriptional control and their impact on cellular_x000D_ function. Oncogene. 2000 May 15;19(21):2468-73._x000D_ _x000D_ _x000D_ , *Frank DA: STAT signaling in the pathogenesis and treatment of cancer. Mol Med. 1999 Jul;5(7):432-56._x000D_ _x000D_ _x000D_ , *Kovarik P, Stoiber D, Eyers PA, Menghini R, Neininger A, Gaestel M, Cohen P, Decker T: Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13956-61._x000D_ _x000D_ _x000D_ |
| Related products: | - Mouse Monoclonal to Syk - Mouse Monoclonal to STIM1 / GOK - Mouse Monoclonal to STRO-1 |
| Shipping condition: | Room temperature |