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Data sheet of Mouse Monoclonal to Sos
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Mouse, Other not determined |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Sos
| Brand: | Exbio |
| Product no.: | 11-522-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Sos |
| Antigen: | Sos |
| Clonality: | Monoclonal |
| Clone: | SOS-01 |
| Isotype: | IgG1 |
| Immunogen: | Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein._x000D_ |
| Format: | purified |
| Specificity: | The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein. _x000D_ |
| Categories: | Signaling of Small GTPases (Human), Signaling of Small GTPases |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization; the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex. _x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| General references: | *Tian X, Feig LA: Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors. J Biol Chem. 2001 Dec 14;276(50):47248-56., *Silver SJ, Chen F, Doyon L, Zink AW, Rebay I: New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function. Genesis. 2004 Aug;39(4):263-72._x000D_ , *Yang L, Bashaw GJ: Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline. Neuron. 2006 Nov 22;52(4):595-607._x000D_ , *Freedman TS, Sondermann H, Friedland GD, Kortemme T, Bar-Sagi D, Marqusee S, Kuriyan J.: A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16692-7., *Innocenti M, Tenca P, Frittoli E, Faretta M, Tocchetti A, Di Fiore PP, Scita G.: Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J Cell Biol. 2002 Jan 7;156(1):125-36. |
| Related products: | - Mouse Monoclonal to STIM1 / GOK - Mouse Monoclonal to STAT1 - Mouse Monoclonal to STAT1 (Phospho-Ser727) |
| Shipping condition: | Room temperature |