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Data sheet of Mouse Monoclonal to SHIP-1
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Other not determined |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to SHIP-1
| Brand: | Exbio |
| Product no.: | 11-525-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to SHIP-1 |
| Antigen: | SHIP-1 |
| Clonality: | Monoclonal |
| Clone: | SHIP-02 |
| Isotype: | IgG2a |
| Immunogen: | Peptide coresponding to a sequence within N-terminal domain of Human SHIP-1._x000D_ |
| Format: | purified |
| Specificity: | The antibody SHIP-02 reacts with SHIP-1, a phosphoinositide phosphatase largely confined to hematopoietic cells. Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 kDa. _x000D_ |
| Categories: | Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human), Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | SHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5´inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI(3,4,5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcgammaRIIB, Fcgamma RIII, FcepsilonRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane._x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| General references: | *Harris SJ, Parry RV, Westwick J, Ward S.G.: Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide_x000D_ 3-kinase signaling in T lymphocytes. J Biol Chem. 2008 Feb 1;283(5):2465-9., *Xing W, Hamaguchi M.: Effects of SHIP-1 on MMP2 secretion and invasion of SR3Y1 cells. J Genet Genomics. 2007 Apr;34(4):285-93., *Tarasenko T, Kole HK, Chi AW, Mentink-Kane MM, Wynn TA, Bolland S.: T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11382-7., *Ai J, Maturu A, Johnson W, Wang Y, Marsh CB, Tridandapani S.: The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1. Blood. 2006 Jan 15;107(2):813-20. |
| Related products: | - Mouse Monoclonal to SLP76 - Mouse Monoclonal to Sialyl Lewis a / CA-19.9 - Mouse Monoclonal to SIT |
| Shipping condition: | Room temperature |