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Data sheet of Mouse Monoclonal to R-Ras2 / TC21
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
| Host species | Mouse |
| Applications | FC, WB, ELISA |
More info about Mouse Monoclonal to R-Ras2 / TC21
| Antigen: | R-Ras2 / TC21 |
| Clone: | EM-50 |
| Isotype: | IgG1 |
| Immunogen: | Human TC21 |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody EM-50 recognizes R-Ras2 / TC21 protein and does not react with R-Ras1, H-Ras, K-Ras, and N-Ras. |
| Categories: | Signaling of Small GTPases (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | R-Ras2 / TC21 is the only member of R-Ras family of small GTPases that shows transforming activities similar to H-Ras, N-Ras, and K-Ras, and it is also structurally similar to them. R-Ras2 seems to play an important role in activating signal transduction pathways that control cell proliferation. Its mutations are associated with the growth of certain tumors, but also overexpression of the wild type form of R-Ras2 has been frequently detected in various carcinomas. Pseudogenes of R-Ras2 gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| General references: | Gutierrez-Erlandsson S, Herrero-Vidal P, Fernandez-Alfara M, Hernandez-Garcia S, Gonzalo-Flores S, Mudarra-Rubio A, Fresno M, Cubelos B: R-RAS2 overexpression in tumors of the human central nervous system. Mol Cancer. 2013 Oct 23;12(1):127., Larive RM, Moriggi G, Menacho-Márquez M, Cañamero M, de Ãlava E, Alarcón B, Dosil M, Bustelo XR: Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease. Nat Commun. 2014 May 14;5:3881. |