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Data sheet of Mouse Monoclonal to PRR7 / TRAP3
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to PRR7 / TRAP3
| Brand: | Exbio |
| Product no.: | 11-617-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to PRR7 / TRAP3 |
| Antigen: | PRR7 / TRAP3 |
| Clonality: | Monoclonal |
| Clone: | TRAP3/10 |
| Isotype: | IgG2a |
| Immunogen: | Recombinant C-terminal half of the intracellular domain of human PRR7/TRAP3 (amino acids 126-253)_x000D_ |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody TRAP3/10 recognizes an epitope located in the C-terminal part of the intracellular domain of PRR7/TRAP3 (amino acids 126-253 of human PRR7 / TRAP3), a 28 kDa proline-rich membrane protein presumably associated with NMDA receptor complex._x000D_ |
| Categories: | Adaptor Proteins, Adaptor Proteins (Rodent), Adaptor Proteins (Human), Neurobiology (Human), Neurobiology (Rodent) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | PRR7/TRAP3 (proline-rich 7, transmembrane adaptor protein 3) is a 28 kDa transmembrane adaptor protein ubiquitously expressed at low level (most in brain). Its amino acid sequence is extremely conserved among mammalian and other species. PRR7/TRAP3 contains potential palmitoylation motif and is found in lipid rafts. It is a part of the complex postsynaptic density fraction in neurons and associates with PSD-95, NMDA receptor and probably other proteins. The intracellular domain of PRR7/TRAP3 contains several tyrosines, a proline-rich sequence, and a C-terminal PDZ-binding motif. So far nothing is known about function of this protein. It may be involved in regulation of some receptor signaling and in formation of neurologic and immunologic synapse._x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Hrdinka M, Dráber P, Stepánek O, Ormsby T, Otáhal P, Angelisová P, Brdicka T, Paces J, Horejsà V, Drbal K: PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. J Biol Chem. 2011 Jun 3;286(22):19617-29 |
| General references: | *Murata Y, Doi T, Taniguchi H, Fujiyoshi Y: Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor. Biochem Biophys Res Commun. 2005 Feb 4;327(1):183-91. |
| Related products: | - Mouse Monoclonal to SCIMP - Mouse Monoclonal to RLTPR / CARMIL2 - Mouse Monoclonal to R-Ras2 / TC21 |
| Shipping condition: | Room temperature |