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Data sheet of Mouse Monoclonal to PLSCR1 (rat)
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Rat |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to PLSCR1 (rat)
| Brand: | Exbio |
| Product no.: | 21-495-R025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to PLSCR1 (rat) |
| Antigen: | PLSCR1 (rat) |
| Clonality: | Monoclonal |
| Clone: | 13A6 [TEC-23] |
| Isotype: | IgG2a |
| Immunogen: | BALB/c mice were immunized with pooled lipid rafts isolated from RBL-2H3 cells. Hybridoma cells were obtained after fusion of SP02 mouse myeloma cells with spleen cells of immunized mice using standard procedures. |
| Format: | ascites |
| Specificity: | The antibody 13A6 [TEC-23] binds to rat Phospholipid Scramblase 1 (PLSCR1), an 37-49 kDa membrane-associated protein accelerating bidirectional movement of plasma membrane phospholipids during conditions of elevated calcium. |
| Categories: | Calcium Signaling (Rodent) |
| Storage buffer: | Undiluted ascitic fuild with 15 mM sodium azide. |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | PLSCR1 (Phospholipid Scramblase 1) is a multiply palmitoylated endofacial plasma membrane protein containing several SH3 and WW domain binding motives. In the plasma membrane, PLSCR1 plays a role in transbilayer lipid redistributions and signal transduction. Nonpalmitoylated PLSCR1, however, is able to be transported into the nucleus and bind DNA. PLSCR1 potentiates the antiviral activity of interferon and its expression is highly induced by interferons and growth factors. _x000D_ |
| Usage: | The antibody is suitable for Western blotting, immunoprecipitation, flow cytometry and immunocytochemistry. |
| Product specific references: | *Smrz D, Lebduska P, Dráberová L, Korb J, Dráber P: Engagement of Phospholipid Scramblase 1 in Activated Cells: IMPLICATION FOR PHOSPHATIDYLSERINE EXTERNALIZATION AND EXOCYTOSIS. J Biol Chem. 2008 Apr 18;283(16):10904-18._x000D_ _x000D_ _x000D_ _x000D_ |
| General references: | *Pastorelli C, Veiga J, Charles N, Voignier E, Moussu H, Monteiro RC, Benhamou M: IgE receptor type I-dependent tyrosine phosphorylation of phospholipid scramblase. J Biol Chem. 2001 Jun 8;276(23):20407-12. Epub 2001 Mar 20., *Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ: Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1. Cancer Res. 2002 Jan 15;62(2):397-402. _x000D_ , *Dong B, Zhou Q, Zhao J, Zhou A, Harty RN, Bose S, Banerjee A, Slee R, Guenther J, Williams BR, Wiedmer T, Sims PJ, Silverman RH: Phospholipid scramblase 1 potentiates the antiviral activity of interferon. J Virol. 2004 Sep;78(17):8983-93. _x000D_ |
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| Shipping condition: | Room temperature |