Cart 0 Product Products (empty)
No products
To be determined Shipping
0,00 € Total
Prices are tax excluded
Product successfully added to your shopping cart
Quantity
Total
There are 0 items in your cart. There is 1 item in your cart.
Total products (tax excl.)
Total shipping (tax excl.) To be determined
Total (tax excl.)
Data sheet of Rabbit Polyclonal to PAG / Cbp
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Mouse, Human |
| Clonality | Polyclonal |
More info about Rabbit Polyclonal to PAG / Cbp
| Brand: | Exbio |
| Product no.: | 11-409-C025 |
| Product type: | Primary antibodies |
| Host species: | Rabbit |
| Product name: | Rabbit Polyclonal to PAG / Cbp |
| Antigen: | PAG / Cbp |
| Clonality: | Polyclonal |
| Clone: | Polyclonal |
| Immunogen: | Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG). |
| Format: | purified |
| Specificity: | The polyclonal antibody recognizes Csk-binding protein (Cbp / PAG), a 46 kDa ubiquitously expressed transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. |
| Categories: | Adaptor Proteins (Rodent), Adaptor Proteins (Human), Adaptor Proteins |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified from rabbit serum by precipitation methods |
| Related products: | - Rabbit Polyclonal to SLP76 - Rabbit Polyclonal to PDK1 / PDPK1 - Rabbit Polyclonal to SLP65 / BLNK |
| Shipping condition: | Room temperature |