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Data sheet of Mouse Monoclonal to p21Waf1
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Non-Human Primates |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to p21Waf1
| Brand: | Exbio |
| Product no.: | 11-338-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to p21Waf1 |
| Antigen: | p21Waf1 |
| Clonality: | Monoclonal |
| Clone: | WA-1 |
| Isotype: | IgG1 |
| Immunogen: | Human p21 protein |
| Format: | purified |
| Specificity: | The antibody WA-1 reacts with p21 protein (Waf1, Cip1, SDI 1), a 21 kDa tumour suppressor, which inhibits the activity of cyclin-dependent family kinases and of proliferating cell nuclear antigen. |
| Categories: | Transcription Regulation & Nuclear Proteins (Veterinary), Transcription Regulation & Nuclear Proteins (Human), Cyclin Signaling (Veterinary), Cyclin Signaling (Human), Cyclin Signaling |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | The tumour suppressor p21Waf1 (Wild-type p53-Activated Fragment 1; also known as Cip1, Cdk interacting protein, or SDI 1) is a cyclin-dependent kinase (Cdk) inhibitor, which is expressed by involvement of p53, Egr-1, AP2, STATs or other transcription factors upon various stimuli resulting in cell cycle arrest. Through its N-terminal domain p21Waf1 inhibits Cdk activity, whereas through the C-terminal domain it inhibits the activity of PCNA (proliferating cell nuclear antigen) to activate DNA replication. Cytosolic location of p21 counteracts its inhibitory activities. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Kolar Z, Murray PG, Scott K, Harrison A, Vojtesek B, Dusek J: Relation of Bcl-2 expression to androgen receptor, p21WAF1/CIP1, and cyclin D1 status in prostate cancer._x000D_ Mol Pathol. 2000 Feb;53(1):15-8. _x000D_ |
| General references: | *Zhang C, Kavurma MM, Lai A, Khachigian LM: Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF/Cip1 promoter. J Biol Chem. 2003 Jul 25;278(30):27903-9. _x000D_ _x000D_ , *Horky M, Kuchtickova S, Vojtesek B, Kolar F: Induction of cell-cycle inhibitor p21 in rat ventricular myocytes during early_x000D_ postnatal transition from hyperplasia to hypertrophy._x000D_ Physiol Res. 1997;46(3):233-5. _x000D_ , *Waga S, Hannon GJ, Beach D, Stillman B: The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature. 1994 Jun 16;369(6481):574-8._x000D_ _x000D_ _x000D_ , *Choi BH, Kim CG, Bae YS, Lim Y, Lee YH, Shin SY: p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. Cancer Res. 2008 Mar 1;68(5):1369-77._x000D_ _x000D_ _x000D_ , *Keeshan K, Cotter TG, McKenna SL: Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1 by a phosphoinositide-3-kinase (PI3K)-independent pathway. Br J Haematol. 2003 Oct;123(1):34-44._x000D_ _x000D_ _x000D_ |
| Related products: | - Mouse Monoclonal to PAG / Cbp - Mouse Monoclonal to p53 (Phospho-Ser392) - Mouse Monoclonal to PAC-1 |
| Shipping condition: | Room temperature |