Mouse Monoclonal to NTAL / LAB View larger

Mouse Monoclonal to NTAL / LAB

New product

128,60 € tax excl.

Customer ratings and reviews

Nobody has posted a review yet
in this language

Data sheet of Mouse Monoclonal to NTAL / LAB

BrandExbio
Product typePrimary antibodies
ReactivityHuman
ClonalityMonoclonal

More info about Mouse Monoclonal to NTAL / LAB

Brand: Exbio
Product no.: 11-373-C025
Product type: Primary antibodies
Host species: Mouse
Product name: Mouse Monoclonal to NTAL / LAB
Antigen: NTAL / LAB
Clonality: Monoclonal
Negative species: Mouse
Clone: NAP-03
Isotype: IgG2a
Immunogen: Peptide corresponding to aa 196-212 of human NTAL coupled to KLH.
Format: purified
Specificity: The antibody NAP-03 recognizes the defined epitope (aa 196-212) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
Categories: Adaptor Proteins (Human), Adaptor Proteins
Concentration: 1 mg/ml
Storage buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage / stability: Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Background: NTAL (Non-T cell Activation Linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Purity: > 95% (by SDS-PAGE)
Purification: Purified by protein-A affinity chromatography
Product specific references: *Brdicka T, Imrich M, Angelisova P, Brdickova N, Horvath O, Spicka J, Hilgert I, Luskova P, Draber P, Novak P, Engels N, Wienands J, Simeoni L, Osterreicher J, Aguado E, Malissen M, Schraven B, Horejsi V: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J Exp Med. 2002 Dec 16;196(12):1617-26. _x000D_
General references: *Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T: LAT and NTAL mediate immunoglobulin E-induced sustained extracellular_x000D_ signal-regulated kinase activation critical for mast cell survival. Mol Cell Biol. 2007 Jun;27(12):4406-15._x000D_
Related products: - Mouse Monoclonal to p53 (Phospho-Ser392)
- Mouse Monoclonal to OPAL1
- Mouse Monoclonal to p21Waf1
Shipping condition: Room temperature

Reviews

Buy Mouse Monoclonal to NTAL / LAB now

Add to cart