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Data sheet of Mouse Monoclonal to NCK1
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to NCK1
| Brand: | Exbio |
| Product no.: | 11-711-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to NCK1 |
| Antigen: | NCK1 |
| Clonality: | Monoclonal |
| Clone: | EM-06 |
| Isotype: | IgG1 |
| Immunogen: | Purified recombinant second SH3 domain of human Nck1 fused to GST |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody EM-06 recognizes NCK1 (NCK alpha), an ubiquitously expressed cytoplasmic SH2/SH3 adaptor protein important for organization of actin cytoskeleton structures. |
| Categories: | Adaptor Proteins (Rodent), Adaptor Proteins (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | NCK1 (NCK alpha) is a cytoplasmic adaptor protein that plays a universal role in coordinating the signaling networks critical for organizing the actin cytoskeleton, cell movement, or axon guidance, connecting transmembrane receptors to multiple intracellular signaling pathways. It contains one SH2 domain, through which NCK1 binds to phosphorylated domains of transmembrane signaling moleculs or certain adaptor proteins, and three SH3 domains for binding proline-rich sequences of other molecules involved in the process of nucleation and polymerization of the actin cytoskeleton. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Borroto A, Arellano I, Dopfer EP, Prouza M, Suchánek M, Fuentes M, Orfao A, Schamel WW, Alarcón B: Nck recruitment to the TCR required for ZAP70 activation during thymic development. J Immunol. 2013 Feb 1;190(3):1103-12. |
| Related products: | - Mouse Monoclonal to Neurofilament medium protein - Mouse Monoclonal to Neurofilament heavy protein - Mouse Monoclonal to Neurofilament heavy protein |
| Shipping condition: | Room temperature |