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Data sheet of Mouse Monoclonal to Lamin C
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Mouse, Other not determined |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Lamin C
| Brand: | Exbio |
| Product no.: | 11-563-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Lamin C |
| Antigen: | Lamin C |
| Clonality: | Monoclonal |
| Clone: | EM-11 |
| Isotype: | IgG2a |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody EM-11 recognizes lamin C, intermediate filament protein of nuclear lamina._x000D_ |
| Categories: | Transcription Regulation & Nuclear Proteins (Rodent), Transcription Regulation & Nuclear Proteins (Human), Cytoskeleton: Intermediate Filaments (Rodent), Cytoskeleton: Intermediate Filaments (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Lamin C is intermediate filament protein localized to the inner nuclear membrane. It is expressed predominantly in terminally differentiated cells and defines the shape and stability of nuclei in mammalian cells. Besides their structural roles, lamin proteins also regulate fundamental aspects of nuclear function and they cross-talk with cell signaling cascades and cell metabolism. Mutations of LMNA gene, encoding lamin A and C proteins, are often associated with pathogenesis of respective cell types, such as of heart myocytes._x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Shimi T, Kittisopikul M, Tran J, Goldman AE, Adam SA, Zheng Y, Jaqaman K, Goldman RD: Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy. Mol Biol Cell. 2015 Nov 5;26(22):4075-86. |
| General references: | *Cortés R, Roselló-Lletà E, Rivera M, MartÃnez-Dolz L, AzorÃn I, Salvador A, Portolés M: The role of the nuclear lamins in the pathogenesis of heart failure in patients undergoing cardiac transplantation. Transplant Proc. 2009 Jul-Aug;41(6):2227-30._x000D_ , *Chen S, Martin C, Maya-Mendoza A, Tang CW, LovricÌ J, Sims PF, Jackson DA: Reduced Expression of Lamin A/C Results in Modified Cell Signaling and Metabolism Coupled with Changes in Expression of Structural Proteins. J Proteome Res. 2009 Oct 15. [Epub ahead of print]_x000D_ , *Saga A, Karibe A, Otomo J, Iwabuchi K, Takahashi T, Kanno H, Kikuchi J, Keitoku M, Shinozaki T, Shimokawa H: Lamin A/C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia. Tohoku J Exp Med. 2009 Aug;218(4):309-16. _x000D_ , *Mounkes LC, Burke B, Stewart CL: The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and cardiovascular diseases. Trends Cardiovasc Med. 2001 Oct;11(7):280-5._x000D_ |
| Related products: | - Mouse Monoclonal to Lck - Mouse Monoclonal to LARGE1 - Mouse Monoclonal to LAT |
| Shipping condition: | Room temperature |