Cart 0 Product Products (empty)
No products
To be determined Shipping
0,00 € Total
Prices are tax excluded
Product successfully added to your shopping cart
Quantity
Total
There are 0 items in your cart. There is 1 item in your cart.
Total products (tax excl.)
Total shipping (tax excl.) To be determined
Total (tax excl.)
Data sheet of Mouse Monoclonal to Kinesin (heavy chain)
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Mouse, Human, Rat, Other not tested, Porcine |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Kinesin (heavy chain)
| Brand: | Exbio |
| Product no.: | 11-391-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Kinesin (heavy chain) |
| Antigen: | Kinesin (heavy chain) |
| Clonality: | Monoclonal |
| Clone: | KN-03 |
| Isotype: | IgM |
| Immunogen: | Enriched fraction of porcine brain kinesin. |
| Format: | purified |
| Specificity: | The antibody KN-03 recognizes heavy chain of conventional kinesin associated with vesicles and with lower affinity with denaturated molecule. It stains Western blots of kinesin-enriched preparations. Epitope mapping (by limited proteolysis of partially purified porcine kinesin) followed by immunoblotting has revealed that antibodies KN-01, KN-02 and KN-03 react with different sets of fragments. The antibody KN-03 well recognizes kinesin bound to taxol-stabilized microtubules._x000D_ |
| Categories: | Cytoskeleton: Tubulin System (Veterinary), Cytoskeleton: Tubulin System (Rodent), Cytoskeleton: Tubulin System (Human), Cytoskeleton: Microtubular System |
| Concentration: | 1 mg/ml |
| Storage buffer: | Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Kinesin belongs to the group of microtubule-associated motor proteins known to convert chemical energy released from nucleoside triphosphates (preferentially from ATP) into mechanical energy. Conventional kinesin, member of the kinesin superfamily comprising more than 100 proteins, is involved in the anterograde vesicle transport in neuronal cells. Kinesin purified from mammalian brain homogenates is a heterotetramer consisting of two heavy (120 to 130 kDa) and two light chains (60 to 70 kDa), resulting in a molecular mass about 400 kDa. Each heavy chain contains an N-terminal globular motordomain with both a microtubule-binding site and an ATPase active center, stalk region responsible for heavy chain dimerization and finally C-terminal globular tail domain, which is implicated in cargo binding. Light chains may have a regulatory function. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by precipitation and chromatography |
| Product specific references: | *Macurek L, Draberova E, Richterova V, Bohm KJ, Draber P: Monoclonal antibodies KN-02 and KN-03 against the heavy chain of kinesin. Hybrid Hybridomics. 2002 Dec;21(6):457-62. |
| Related products: | - Mouse Monoclonal to Lamin C - Mouse Monoclonal to Ku80 Antigen / DNA helicase p80 - Mouse Monoclonal to Lambda light chains |
| Shipping condition: | Room temperature |