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Data sheet of Mouse Monoclonal to IgE
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to IgE
| Brand: | Exbio |
| Product no.: | 11-326-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to IgE |
| Antigen: | IgE |
| Clonality: | Monoclonal |
| Clone: | 4H10 |
| Isotype: | IgG1 |
| Immunogen: | Purified human IgE. |
| Format: | purified |
| Specificity: | The antibody 4H10 reacts with human IgE; it recognizes an epitope different from the ones recognized by BE5 and 4G7 antibodies to IgE. The epitope is located within the amino acids 267-279 (TWLEDGQVMDVDL). |
| Categories: | Immunoglobulins (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Immunoglobulin E (IgE) is a 180 kDa soluble protein serving as an antigen-specific unit of mast cell effector mechanisms. IgE has the lowest serum concentration of all immunoglobulins (approximately 0.5 mg/l) in healthy individuals, but upon allergen challenge its concentration in blood increases dramatically. Although biological survival of free IgE is very short (T1/2 = 2 days), it is stabilized after binding to its high affinity receptor. Unlike IgM- IgG- and IgA-committed B cells, IgE-switched B cells do not undergo clonal expansion. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by precipitation and chromatography |
| Product specific references: | *ÐС ÐлÑхнович, Ð’Ð’ Янченко, ЕГ ÐÑирÑн, ВП Мартинович, ВП Голубович: Ð’Ñ‹Ñвление IgE-позитивных лейкоцитов крови ÑинтетичеÑким пептидом и моноклональными антителами. Immunopathology, allergology, infectology 2016, no.2, pages 28-34 |
| General references: | *Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975;194:77-95., *Brinkmann V, Heusser CH: T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE_x000D_ plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell Immunol. 1993 Dec;152(2):323-32._x000D_ _x000D_ _x000D_ , *Balogh Z, Merétey K, Falus A, Bozsóky S: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr;39(2):129-34._x000D_ , *Fuller JM, Keyser JW: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May;21(6):667-71., *Gould HJ, Beavil RL, Vercelli D: IgE isotype determination: epsilon-germline gene transcription, DNA recombination and B-cell differentiation. Br Med Bull. 2000;56(4):908-24._x000D_ _x000D_ |
| Related products: | - Mouse Monoclonal to IgM - Mouse Monoclonal to IgG (Fab) - Mouse Monoclonal to IgG (Fc) |
| Shipping condition: | Room temperature |