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Data sheet of Mouse Monoclonal to HIV protease
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | HIV |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to HIV protease
| Brand: | Exbio |
| Product no.: | 11-302-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to HIV protease |
| Antigen: | HIV protease |
| Clonality: | Monoclonal |
| Clone: | 1696 |
| Isotype: | IgG1 |
| Immunogen: | Bacterially expressed full-length HIV-1 protease |
| Format: | purified |
| Specificity: | The antibody 1696 recognizes free N-terminus of mature HIV protease (HIV-1 and HIV-2), an enzyme that hydrolyzes polyproteins of HIV viruses into functional proteins. The antibody 1696 does not react with the precursor. |
| Categories: | Virology and Microbiology |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | The HIV protease (PR) hydrolyzes polyproteins of HIV virus into functional protein products that are essential for its assembly and subsequent activity. This maturation process occurs as the virion buds from the host cell. HIV protease inhibitors are used in the treatment of patients with AIDS and were considered the first breakthrough in over a decade of AIDS research. HIV protease inhibitors can lower the viral load carried by AIDS patents. _x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Bartonová V, Král V, Sieglová I, Brynda J, Fábry M, Horejsà M, KozÃsek M, Sasková KG, Konvalinka J, Sedlácek J, Rezácová P: Potent inhibition of drug-resistant HIV protease variants by monoclonal_x000D_ antibodies. Antiviral Res. 2008 Jun;78(3):275-7. Epub 2008 Feb 20._x000D_ _x000D_ _x000D_ , *Lescar J, Brynda J, Rezacova P, Stouracova R, Riottot MM, Chitarra V, Fabry M, Horejsi M, Sedlacek J, Bentley GA: Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody. Protein Sci. 1999 Dec;8(12):2686-96. _x000D_ , *O'Loughlin TL, Greene DN, Matsumura I: Diversification and specialization of HIV protease function during in vitro evolution. Mol Biol Evol. 2006 Apr;23(4):764-72. _x000D_ |
| General references: | *Kovalevsky AY, Chumanevich AA, Liu F, Louis JM, Weber IT: Caught in the Act: the 1.5 A resolution crystal structures of the HIV-1 protease and the I54V mutant reveal a tetrahedral reaction intermediate. Biochemistry. 2007 Dec 25;46(51):14854-64._x000D_ _x000D_ , *Lapins M, Eklund M, Spjuth O, Prusis P, Wikberg JE: Proteochemometric modeling of HIV protease susceptibility. BMC Bioinformatics. 2008 Apr 10;9(1):181 _x000D_ _x000D_ , *Brower ET, Bacha UM, Kawasaki Y, Freire E: Inhibition of HIV-2 protease by HIV-1 protease inhibitors in clinical use. Chem Biol Drug Des. 2008 Apr;71(4):298-305._x000D_ _x000D_ , *Velazquez-Campoy A, Todd MJ, Vega S, Freire E: Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6062-7._x000D_ _x000D_ |
| Related products: | - Mouse Monoclonal to HLA-ABCE - Mouse Monoclonal to HIV-1 Capsid protein p24 - Mouse Monoclonal to HLA-A2 |
| Shipping condition: | Room temperature |