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Data sheet of Rabbit Polyclonal to Grb2
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Other species Not tested |
| Clonality | Polyclonal |
More info about Rabbit Polyclonal to Grb2
| Brand: | Exbio |
| Product no.: | 11-554-C025 |
| Product type: | Primary antibodies |
| Host species: | Rabbit |
| Product name: | Rabbit Polyclonal to Grb2 |
| Antigen: | Grb2 |
| Clonality: | Polyclonal |
| Clone: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217). |
| Format: | purified |
| Specificity: | The polyclonal antibody recognizes Grb2, a highly conserved approximately 26 kDa adaptor protein. The immunogen has 100% identity between man, cow, rat and mouse._x000D_ |
| Categories: | Signaling of Small GTPases, Signaling of Small GTPases (Human), Adaptor Proteins (Human), Adaptor Proteins |
| Concentration: | 1 mg/ml |
| Storage buffer: | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide. |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling._x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified from rabbit serum by affinity chromatography |
| General references: | *den Hertog J, Hunter T: Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains. EMBO J. 1996 Jun 17;15(12):3016-27._x000D_ , *Reif K, Buday L, Downward J, Cantrell DA: SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. J Biol Chem. 1994 May 13;269(19):14081-7._x000D_ , *Sieh M, Batzer A, Schlessinger J, Weiss A: GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol Cell Biol. 1994 Jul;14(7):4435-42._x000D_ |
| Related products: | - Rabbit Polyclonal to MEK 1/2 / MAPKK 1/2 - Rabbit Polyclonal to Kinesin - Rabbit Polyclonal to LIME |
| Shipping condition: | Room temperature |