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Data sheet of Mouse Monoclonal to Gamma-tubulin complex component 2
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Porcine, Mouse, Rat |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Gamma-tubulin complex component 2
| Brand: | Exbio |
| Product no.: | 11-695-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Gamma-tubulin complex component 2 |
| Antigen: | Gamma-tubulin complex component 2 |
| Clonality: | Monoclonal |
| Clone: | GCP2-01 |
| Isotype: | IgG2b |
| Immunogen: | GST-fusion protein containing amino acids 2-194 of mouse GCP2 |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody GCP2-01 recognizes gamma-tubulin complex component 2 (GCP2), a 95-103 kDa protein. It recognizes also phosphorylated GCP2. |
| Categories: | Cytoskeleton: Tubulin System (Veterinary), Cytoskeleton: Tubulin System (Rodent), Cytoskeleton: Tubulin System (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Gamma tubulin complex component 2 (GCP2) is 95-103 kDa protein which associates with two molecules of gamma tubulin and one molecule of gamma tubulin complex component 3 (GCP3), to form the gamma tubulin small complexes (gammaTuSCs). These complexes interact with GCP4, 5, and 6 to form the gamma tubulin ring complexes (gammaTuRCs), which are embedded in the microtubule organizing center matrix where they nucleate microtubules. The gammaTuRCs are also involved in the regulation of microtubule plus and minus end dynamics. Components of gamma tubulin complexes are highly conservative in eukaryotes. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Dráberová E, D'Agostino L, Caracciolo V, Sládková V, Sulimenko T, Sulimenko V, Sobol M, Maounis NF, Tzelepis E, Mahera E, Křen L, Legido A, Giordano A, Mörk S, Hozák P, Dráber P, Katsetos CD: Overexpression and Nucleolar Localization of γ-Tubulin Small Complex Proteins GCP2 and GCP3 in Glioblastoma. J Neuropathol Exp Neurol. 2015 Jul;74(7):723-42., *Hořejšà B, Vinopal S, Sládková V, Dráberová E, Sulimenko V, Sulimenko T, Vosecká V, Philimonenko A, Hozák P, Katsetos CD, Dráber P: Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53. J Cell Physiol. 2012 Jan;227(1):367-82. |
| General references: | *Bouissou A, Vérollet C, Sousa A, Sampaio P, Wright M, Sunkel CE, Merdes A, Raynaud-Messina B. {gamma}-Tubulin ring complexes regulate microtubule plus end dynamics. J Cell Biol. 2009 Nov 2;187(3):327-34. |
| Related products: | - Mouse Monoclonal to GCPII / PSMA - Mouse Monoclonal to GAPDHS - Mouse Monoclonal to GARP / LRRC32 |
| Shipping condition: | Room temperature |