Brand | Exbio |
Product type | Primary antibodies |
Reactivity | Mouse, Rat, Other species Not tested |
Clonality | Polyclonal |
Brand: | Exbio |
Product no.: | 11-551-C100 |
Product type: | Primary antibodies |
Host species: | Rabbit |
Product name: | Rabbit Polyclonal to GABA(B) R2 |
Antigen: | GABA(B) R2 |
Clonality: | Polyclonal |
Clone: | Polyclonal |
Immunogen: | Synthetic peptide (coupled with THG) derived from the last 23 aa of mouse GABA B receptor 2. 100% homology with human GB2._x000D_ |
Format: | purified |
Specificity: | The polyclonal antibody recognizes C-terminus of gamma-aminobutyric acid (GABA) B receptor 2 (recognized epitope: the last 23 aa). GB2 apparent MW ~120 kDa._x000D_ |
Categories: | Neurobiology (Rodent) |
Concentration: | 1 mg/ml |
Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
Background: | GABA B receptor is a G-protein-coupled inhibitory receptor of gamma-aminobutyric acid (GABA), and has important functions in brain by inhibition of adenylyl cyclase and modulation of G-protein-gated Ca2+ and K+ channels. GABA B receptor is comprised of two subunits, GB1 and GB2 with N-terminal extracellular and C-terminal intracellular domains. The GB1 subunit plays a critical role in ligand binding, whereas the GB2 subunit contains the determinants required for G-protein signaling. Multiple allosteric interactions between the two subunits are required for correct functioning of the receptor. There are two N-terminal splice variants of GB1 subunit, termed GB1a and GB1b; their expression in the central nervous system changes during the ontogenesis and differs between various regions of the brain. |
Purity: | > 95% (by SDS-PAGE) |
Purification: | Purified from rabbit serum by affinity chromatography |
General references: | *Kniazeff J, Galvez T, Labesse G, Pin JP: No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits. J Neurosci. 2002 Sep 1;22(17):7352-61., *Margeta-Mitrovic M, Jan YN, Jan LY: Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14649-54., *Margeta-Mitrovic M, Jan YN, Jan LY: Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14643-8., *Ng GY, Bertrand S, Sullivan R, Ethier N, Wang J, Yergey J, Belley M, Trimble L, Bateman K, Alder L, Smith A, McKernan R, Metters K, O'Neill GP, Lacaille JC, Hébert TE: Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant_x000D_ gabapentin action. Mol Pharmacol. 2001 Jan;59(1):144-52., *Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, Bettler B, Prézeau L, Pin JP: Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J. 2001 May 1;20(9):2152-9., *Fritschy JM, Meskenaite V, Weinmann O, Honer M, Benke D, Mohler H: GABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization. Eur J Neurosci. 1999 Mar;11(3):761-8. |
Related products: | - Rabbit Polyclonal to Kinesin - Rabbit Polyclonal to GFP / Green Fluorescent Protein - Rabbit Polyclonal to Grb2 |
Shipping condition: | Room temperature |