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Data sheet of Rabbit Polyclonal to GABA(B) R1a
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Mouse, Rat, Other species Not tested |
| Clonality | Polyclonal |
More info about Rabbit Polyclonal to GABA(B) R1a
| Brand: | Exbio |
| Product no.: | 11-549-C100 |
| Product type: | Primary antibodies |
| Host species: | Rabbit |
| Product name: | Rabbit Polyclonal to GABA(B) R1a |
| Antigen: | GABA(B) R1a |
| Clonality: | Polyclonal |
| Clone: | Polyclonal |
| Immunogen: | Synthetic peptide (coupled with THG) derived from aminoacid sequence 100-124 of mouse GABA B receptor 1. The sequence has 100% homology with rat and human. |
| Format: | purified |
| Specificity: | The polyclonal antibody recognizes N-terminus of mouse gamma-aminobutyric acid (GABA) B receptor 1a. GB1a apparent MW ~130 kDa._x000D_ _x000D_ |
| Categories: | Neurobiology (Rodent) |
| Concentration: | 1.0 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | GABA B receptor is a G-protein-coupled inhibitory receptor of gamma-aminobutyric acid (GABA), and has important functions in brain by inhibition of adenylyl cyclase and modulation of G-protein-gated Ca2+ and K+ channels. GABA B receptor is comprised of two subunits, GB1 and GB2 with N-terminal extracellular and C-terminal intracellular domains. The GB1 subunit plays a critical role in ligand binding, whereas the GB2 subunit contains the determinants required for G-protein signaling. Multiple allosteric interactions between the two subunits are required for correct functioning of the receptor. There are two N-terminal splice variants of GB1 subunit, termed GB1a and GB1b; their expression in the central nervous system changes during the ontogenesis and differs between various regions of the brain. |
| Purity: | > 80 % (by SDS-PAGE) |
| Purification: | Purified from rabbit serum by precipitation methods |
| General references: | *Kniazeff J, Galvez T, Labesse G, Pin JP: No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits. J Neurosci. 2002 Sep 1;22(17):7352-61., *Margeta-Mitrovic M, Jan YN, Jan LY: Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14649-54., *Margeta-Mitrovic M, Jan YN, Jan LY: Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14643-8., *Ng GY, Bertrand S, Sullivan R, Ethier N, Wang J, Yergey J, Belley M, Trimble L, Bateman K, Alder L, Smith A, McKernan R, Metters K, O'Neill GP, Lacaille JC, Hébert TE: Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant_x000D_ gabapentin action. Mol Pharmacol. 2001 Jan;59(1):144-52., *Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, Bettler B, Prézeau L, Pin JP: Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J. 2001 May 1;20(9):2152-9., *Fritschy JM, Meskenaite V, Weinmann O, Honer M, Benke D, Mohler H: GABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization. Eur J Neurosci. 1999 Mar;11(3):761-8. |
| Related products: | - Rabbit Polyclonal to GFP / Green Fluorescent Protein - Rabbit Polyclonal to GABA(B) R1b - Rabbit Polyclonal to GABA(B) R2 |
| Shipping condition: | Room temperature |