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Data sheet of Mouse Monoclonal to Fyn
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Mouse, Human, Other not tested |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Fyn
| Brand: | Exbio |
| Product no.: | 11-375-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Fyn |
| Antigen: | Fyn |
| Clonality: | Monoclonal |
| Clone: | FYN-01 |
| Isotype: | IgG2b |
| Immunogen: | Bacterially expressed recombinant fragment of human Fyn (aa 7-176). |
| Format: | purified |
| Specificity: | The antibody FYN-01 reacts with Fyn, a 59 kDa non-receptor Src-family protein tyrosine kinase._x000D_ |
| Categories: | Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Rodent), Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human), Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Fyn is a ubiquitously expressed Src-family protein tyrosine kinase with important roles e.g. in immune and nervous system. It regulates N-methyl-D-aspartate (NMDA) receptor functions, thus affecting various brain functions, and even many of its other substrates are important for neural migration, synaptic plasticity, oligodendrocyte differentiation, and axon growth and guidance. In immune system Fyn namely regulates the commitment of T cells to activation, is important in T cell anergy induction, promotes mast cell chemotaxis and reorganization of cytoskeleton and participates in mast cell activation. Fyn is also involved in embryonic stem cell growth and differentiation, associates with tubulin and may play roles in mitotic spindle formation. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Meraner P, Horejsà V, Wolpl A, Fischer GF, Stingl G, Maurer D: Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase_x000D_ activation. J Immunol. 2007 Feb 15;178(4):2262-71._x000D_ |
| General references: | *Rivera J, Olivera A: A current understanding of Fc epsilon RI-dependent mast cell activation. Curr Allergy Asthma Rep. 2008 Mar;8(1):14-20._x000D_ _x000D_ _x000D_ , *Makinodan E, Manabe T, Makinodan M, Yamauchi T, Matsuyoshi H, Sakumura R, Tatsumi K, Wanaka A. A novel role for Fyn: change in sphere formation ability in murine embryonic stem cells. Neuroscience. 2007 Jun 15;147(1):1-4._x000D_ _x000D_ , *Samayawardhena LA, Kapur R, Craig AW: Involvement of Fyn kinase in Kit and integrin-mediated Rac activation,_x000D_ cytoskeletal reorganization, and chemotaxis of mast cells. Blood. 2007 May 1;109(9):3679-86._x000D_ _x000D_ , *Filby A, Seddon B, Kleczkowska J, Salmond R, Tomlinson P, Smida M, Lindquist JA, Schraven B, Zamoyska R. Fyn regulates the duration of TCR engagement needed for commitment to effector function. J Immunol. 2007 Oct 1;179(7):4635-44._x000D_ _x000D_ _x000D_ , *Wu HY, Hsu FC, Gleichman AJ, Baconguis I, Coulter DA, Lynch DR: Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B_x000D_ cleavage in neurons and heterologous systems. J Biol Chem. 2007 Jul 13;282(28):20075-87._x000D_ _x000D_ , *Hattori K, Uchino S, Isosaka T, Maekawa M, Iyo M, Sato T, Kohsaka S, Yagi T, Yuasa S: Fyn is required for haloperidol-induced catalepsy in mice. J Biol Chem. 2006 Mar 17;281(11):7129-35._x000D_ _x000D_ , *Talmor-Cohen A, Tomashov-Matar R, Tsai WB, Kinsey WH, Shalgi R: Fyn kinase-tubulin interaction during meiosis of rat eggs. Reproduction. 2004 Oct;128(4):387-93._x000D_ _x000D_ _x000D_ , *Utting O, Priatel JJ, Teh SJ, Teh HS: p59fyn (Fyn) promotes the survival of anergic CD4-CD8- alpha beta TCR+ cells but negatively regulates their proliferative response to antigen stimulation. J Immunol. 2001 Feb 1;166(3):1540-6._x000D_ _x000D_ _x000D_ |
| Related products: | - Mouse Monoclonal to Gamma-tubulin complex component 2 - Mouse Monoclonal to gamma-tubulin - Mouse Monoclonal to gamma-tubulin 1 |
| Shipping condition: | Room temperature |