Cart 0 Product Products (empty)
No products
To be determined Shipping
0,00 € Total
Prices are tax excluded
Product successfully added to your shopping cart
Quantity
Total
There are 0 items in your cart. There is 1 item in your cart.
Total products (tax excl.)
Total shipping (tax excl.) To be determined
Total (tax excl.)
Data sheet of Mouse Monoclonal to EGFR (Phospho-Tyr992)
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to EGFR (Phospho-Tyr992)
| Brand: | Exbio |
| Product no.: | 11-574-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to EGFR (Phospho-Tyr992) |
| Antigen: | EGFR (Phospho-Tyr992) |
| Clonality: | Monoclonal |
| Clone: | EM-12 |
| Isotype: | IgG1 |
| Immunogen: | Synthetic phospho-peptide covering sequence around tyrosine 992 of human EGFR._x000D_ |
| Format: | purified |
| Specificity: | The antibody EM-12 reacts with human EGFR (ErbB1 / HER1) phosphorylated on tyrosine 992._x000D_ |
| Categories: | Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| General references: | *Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM Jr, Cover TL, Washington MK, Wilson KT, Polk DB: Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology. 2009 Apr;136(4):1297-1307, e1-3., *Gandhi J, Zhang J, Xie Y, Soh J, Shigematsu H, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Varella-Garcia M, Minna JD, Gazdar AF: Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS ONE. 2009;4(2):e4576., *Rappl A, Piontek G, Schlegel J: EGFR-dependent migration of glial cells is mediated by reorganisation of N-cadherin. J Cell Sci. 2008 Dec 15;121(Pt 24):4089-97._x000D_ , *Daniele T, Di Tullio G, Santoro M, Turacchio G, De Matteis MA: ARAP1 regulates EGF receptor trafficking and signalling. Traffic. 2008 Dec;9(12):2221-35._x000D_ , *Batzer AG, Blaikie P, Nelson K, Schlessinger J, Margolis B: The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the_x000D_ epidermal growth factor receptor. Mol Cell Biol. 1995 Aug;15(8):4403-9._x000D_ , *Moulder SL, Yakes FM, Muthuswamy SK, Bianco R, Simpson JF, Arteaga CL: Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res. 2001 Dec 15;61(24):8887-95._x000D_ |
| Related products: | - Mouse Monoclonal to Fyn - Mouse Monoclonal to FOLR2 - Mouse Monoclonal to FoxP3 |
| Shipping condition: | Room temperature |