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Data sheet of Mouse Monoclonal to EGFR
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Equine (Horse) |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to EGFR
| Brand: | Exbio |
| Product no.: | 11-680-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to EGFR |
| Antigen: | EGFR |
| Clonality: | Monoclonal |
| Negative species: | Mouse |
| Clone: | EGFR1 |
| Isotype: | IgG2b |
| Immunogen: | Human epidermoid carcinoma line A431 |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1); epitope within amino acids 6-273. |
| Categories: | Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Fortunel NO, Hatzfeld JA, Rosemary PA, Ferraris C, Monier MN, Haydont V, Longuet J, Brethon B, Lim B, Castiel I, Schmidt R, Hatzfeld A: Long-term expansion of human functional epidermal precursor cells: promotion of extensive amplification by low TGF-beta1 concentrations. J Cell Sci. 2003 Oct 1;116(Pt 19):4043-52., *Rebetz J, Tian D, Persson A, Widegren B, Salford LG, Englund E, Gisselsson D, Fan X: Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma. PLoS One. 2008 Apr 9;3(4):e1936., *Akiyama M, Smith LT, Shimizu H: Changing patterns of localization of putative stem cells in developing human hair_x000D_ follicles. J Invest Dermatol. 2000 Feb;114(2):321-7., *Aigner A, Juhl H, Malerczyk C, Tkybusch A, Benz CC, Czubayko F: Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation. Oncogene. 2001 Apr 19;20(17):2101-11. |
| Related products: | - Mouse Monoclonal to FOLR2 - Mouse Monoclonal to EGFR (Phospho-Tyr1173) - Mouse Monoclonal to EGFR (Phospho-Tyr992) |
| Shipping condition: | Room temperature |