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Data sheet of Mouse Monoclonal to DDIT4L
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to DDIT4L
| Brand: | Exbio |
| Product no.: | 11-725-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to DDIT4L |
| Antigen: | DDIT4L |
| Clonality: | Monoclonal |
| Clone: | DDIT-03 |
| Isotype: | IgG1 |
| Immunogen: | N-terminal recombinant fragment of human DDIT4L (amino acids 2-98) |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody DDIT-03 recognizes DDIT4L / REDD2 protein, which belongs to stress-induced proteins involved in mediation of cell death. |
| Categories: | Apoptosis (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | DDIT4L (DNA-damage-inducible transcript 4-like), also known as REDD2 (regulated in development and DNA damage response 2) or RTP801L is a stress-inducted protein, which was shown to mediate monocyte cell death through a reduction in thioredoxin-1 expression, and is highly expressed in atherosclerotic lesions. Stimulation of DDIT4L expression in macrophages increases oxidized LDL-induced macrophage death. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| General references: | *Cuaz-Pérolin C, Furman C, Larigauderie G, Legedz L, Lasselin C, Copin C, Jaye M, Searfoss G, Yu KT, Duverger N, Nègre-Salvayre A, Fruchart JC, Rouis M.REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1830-5., *Corradetti MN, Inoki K, Guan KL: The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005 Mar 18;280(11):9769-72. , *Imen JS, Billiet L, Cuaz-Pérolin C, Michaud N, Rouis M: The regulated in development and DNA damage response 2 (REDD2) gene mediates human monocyte cell death through a reduction in thioredoxin-1 expression. Free Radic Biol Med. 2009 May 15;46(10):1404-10 |
| Related products: | - Mouse Monoclonal to Drebrin - Mouse Monoclonal to DLL4 - Mouse Monoclonal to DR3 / TRAMP |
| Shipping condition: | Room temperature |