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Data sheet of Mouse Monoclonal to Daxx / DAP6
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Daxx / DAP6
| Brand: | Exbio |
| Product no.: | 11-517-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Daxx / DAP6 |
| Antigen: | Daxx |
| Clonality: | Monoclonal |
| Clone: | DAXX-03 |
| Isotype: | IgG1 |
| Immunogen: | His6-tagged protein corresponding to amino acids 580-740 of human Daxx. |
| Format: | purified |
| Specificity: | The antibody DAXX-03 reacts with C-terminal part of Daxx, a 110 kDa intracellular protein. |
| Categories: | Transcription Regulation & Nuclear Proteins (Human), Apoptosis (Human), Transcription Regulation & Nuclear Proteins, Apoptosis |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Daxx is an apoptosis-modulating death-domain associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1). |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis. 2008 Mar;13(3):423-36._x000D_ |
| General references: | *Jung YS, Kim HY, Kim J, Lee MG, Pouysségur J, Kim E: Physical Interactions and Functional Coupling between Daxx and Sodium Hydrogen Exchanger 1 in Ischemic Cell Death. J Biol Chem. 2008 Jan 11;283(2):1018-25._x000D_ _x000D_ , *Shih HM, Chang CC, Kuo HY, Lin DY: Daxx mediates SUMO-dependent transcriptional control and subnuclear_x000D_ compartmentalization. Biochem Soc Trans. 2007 Dec;35(Pt 6):1397-400._x000D_ _x000D_ _x000D_ , *Li Q, Wang X, Wu X, Rui Y, Liu W, Wang J, Wang X, Liou YC, Ye Z, Lin SC: Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer Res. 2007 Jan 1;67(1):66-74._x000D_ _x000D_ , *Croxton R, Puto LA, de Belle I, Thomas M, Torii S, Hanaii F, Cuddy M, Reed JC. Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear_x000D_ factor-kappaB. Cancer Res. 2006 Sep 15;66(18):9026-35._x000D_ _x000D_ _x000D_ , *Muromoto R, Ishida M, Sugiyama K, Sekine Y, Oritani K, Shimoda K, Matsuda T: Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and_x000D_ the hormone receptor-mediated transactivation. J Immunol. 2006 Jul 15;177(2):1160-70._x000D_ _x000D_ _x000D_ |
| Related products: | - Mouse Monoclonal to DLL4 - Mouse Monoclonal to DDDDK tag - Mouse Monoclonal to DDIT4L |
| Shipping condition: | Room temperature |