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Data sheet of Mouse Monoclonal to Daxx / DAP6
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Daxx / DAP6
| Brand: | Exbio |
| Product no.: | 11-351-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Daxx / DAP6 |
| Antigen: | Daxx |
| Clonality: | Monoclonal |
| Clone: | DAXX-01 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant C-terminal part (aa 558-740) of human Daxx. |
| Format: | purified |
| Specificity: | The antibody DAXX-01 reacts with Daxx, a death domain containing protein mainly expressed in fetal and adult human and mouse tissue. |
| Categories: | Transcription Regulation & Nuclear Proteins (Human), Apoptosis (Human), Transcription Regulation & Nuclear Proteins, Apoptosis |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Daxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1)._x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Leal-Sanchez J, Couzinet A, Rossin A, Abdel-Sater F, Chakrabandhu K, Luci C, Anjuere F, Stebe E, Hancock D, Hueber AO.: Requirement for Daxx in mature T-cell proliferation and activation. Cell Death Differ. 2007 Apr;14(4):795-806. |
| Related products: | - Mouse Monoclonal to DLL4 - Mouse Monoclonal to DDDDK tag - Mouse Monoclonal to DDIT4L |
| Shipping condition: | Room temperature |