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Data sheet of Rabbit Polyclonal to CtBP1 / BARS
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Mouse |
| Clonality | Polyclonal |
More info about Rabbit Polyclonal to CtBP1 / BARS
| Brand: | Exbio |
| Product no.: | 11-511-C100 |
| Product type: | Primary antibodies |
| Host species: | Rabbit |
| Product name: | Rabbit Polyclonal to CtBP1 / BARS |
| Antigen: | CtBP1 |
| Clonality: | Polyclonal |
| Clone: | Polyclonal |
| Immunogen: | Bacterially expressed full-length human CtBP1 |
| Format: | purified |
| Specificity: | The polyclonal antibody reacts with CtBP1, a 49 kDa transcriptional corepressor, that plays a critical role in regulating gene expression. |
| Categories: | Transcription Regulation & Nuclear Proteins (Rodent), Transcription Regulation & Nuclear Proteins (Human), Transcription Regulation & Nuclear Proteins |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | C-terminal binding protein 1 / brefeldin A (BFA)-dependent ADP-ribosylation substrate (CtBP1/BARS) is a highly conserved transcriptional corepressor, that plays a critical role in regulating gene expression patterns throughout development and in oncogenesis. CtBP regulates target gene transcription, in part, via recruitment of histone deacetylases involved in gene silencing and may act to coordonate histone modifications that regulate gene expression. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified from rabbit serum by affinity chromatography |
| Product specific references: | *Valenta T, Lukas J, Doubravska L, Fafilek B, Korinek V: HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. EMBO J. 2006 Jun 7;25(11):2326-37. |
| General references: | *Valenta T, Lukas J, Korinek V: HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells._x000D_ Nucleic Acids Res. 2003 May 1;31(9):2369-80._x000D_ , *Nadauld LD, Phelps R, Moore BC, Eisinger A, Sandoval IT, Chidester S, Peterson PW, Manos EJ, Sklow B, Burt RW, Jones DA: Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases. J Biol Chem. 2006 Dec 8;281(49):37828-35. , *Lopez-Garcia J, Periyasamy M, Thomas RS, Christian M, Leao M, Jat P, Kindle KB, Heery DM, Parker MG, Buluwela L, Kamalati T, Ali S.: ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. Nucleic Acids Res. 2006; 34(21):6126-36. |
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| Shipping condition: | Room temperature |