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Data sheet of Mouse Monoclonal to Clathrin heavy chain
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Porcine, Mouse, Rat, Bovine, Other not determined |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Clathrin heavy chain
| Brand: | Exbio |
| Product no.: | 11-526-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Clathrin heavy chain |
| Antigen: | Clathrin heavy chain |
| Clonality: | Monoclonal |
| Clone: | BF-06 |
| Isotype: | IgM |
| Format: | purified |
| Specificity: | The antibody BF-06 recognizes clathrin heavy chain, an ubiquitously expressed 180 kDa protein involved in receptor-mediated endocytosis. _x000D_ |
| Categories: | Endocytosis (Veterinary), Endocytosis (Rodent), Endocytosis (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Stabilising Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Clathrin is a submembrane protein that polymerizes into coat-like lattices, which results in membrane invagination. The basic oligomers are composed of three clathrin heavy chain (180 kDa) and three light chain (30 kDa) subunits and the process of polymerization is dynamically regulated by the light chains. Interaction of clathrin with the plasma membrane is mediated by adaptor proteins (AP1-4) specific for different cellular compartments. Another proteins, such as endophilin, epsin and amphiphysin are involved in membrane invagination and clathrin rearrangements. Finally, dynamin functions at the fission stage of clathrin-mediated endocytosis. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by precipitation and chromatography |
| Product specific references: | *Macurek L, Zikova M, Draberova E, Draber P: Monoclonal antibody BF-06 against the heavy chain of clathrin. Folia Biol (Praha). 2003;49(6):238-40._x000D_ |
| General references: | *Wilbur JD, Hwang PK, Brodsky FM: New faces of the familiar clathrin lattice. Traffic. 2005 Apr;6(4):346-50._x000D_ , *Szymkiewicz I, Shupliakov O, Dikic I: Cargo- and compartment-selective endocytic scaffold proteins. Biochem J. 2004 Oct 1;383(Pt 1):1-11._x000D_ , *Smith CJ, Pearse BM: Clathrin: anatomy of a coat protein. Trends Cell Biol. 1999 Sep;9(9):335-8._x000D_ |
| Related products: | - Mouse Monoclonal to c-Myc / Cellular myelocytomatosis oncogene - Mouse Monoclonal to CLIC5a - Mouse Monoclonal to Clusterin / Apolipoprotein J |
| Shipping condition: | Room temperature |