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Data sheet of Mouse Monoclonal to CD81
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Feline (Cat), Rabbit |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD81
| Brand: | Exbio |
| Product no.: | 11-558-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD81 |
| Antigen: | CD81 |
| Clonality: | Monoclonal |
| Clone: | M38 |
| Isotype: | IgG1 |
| Immunogen: | MOLT-4 (human T-ALL cell line)_x000D_ |
| Format: | purified |
| Specificity: | The antibody M38 reacts with CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells._x000D_ |
| Categories: | CD Antigens & MHC (Veterinary), CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells – e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *StehlÃková O, Chovancová J, Tichý B, KrejÄà M, Brychtová Y, Panovská A, Francová Skuhrová H, BurÄková K, Borský M, Loja T, Mayer J, PospÃÅ¡ilová S, Doubek M: Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice. Int J Lab Hematol. 2013 Sep 13. doi: 10.1111/ijlh.12149., *Fukudome K, Furuse M, Imai T, Nishimura M, Takagi S, Hinuma Y, Yoshie O: Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells. J Virol. 1992 Mar;66(3):1394-401., *Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ: Selective enrichment of tetraspan proteins on the internal vesicles of_x000D_ multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem. 1998 Aug 7;273(32):20121-7.", *Imai T, Kakizaki M, Nishimura M, Yoshie O: Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. J Immunol. 1995 Aug 1;155(3):1229-39., *Imai T, Yoshie O: C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells. J Immunol. 1993 Dec 1;151(11):6470-81. |
| Related products: | - Mouse Monoclonal to CD84 - Mouse Monoclonal to CD82 - Mouse Monoclonal to CD83 |
| Shipping condition: | Room temperature |