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Data sheet of Mouse Monoclonal to CD66acde
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD66acde
| Brand: | Exbio |
| Product no.: | 11-592-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD66acde |
| Antigen: | CD66acde |
| Clonality: | Monoclonal |
| Clone: | CLB-gran/10 |
| Isotype: | IgG1 |
| Immunogen: | Human granulocytes |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody CLB-gran/10 (IH4Fc) detects human CD66acde antigen, a granulocyte marker, especially after cell stimulation. The antibody does not cross-react with normal human peripheral B cells, T cells, monocytes and platelets. Weak reactivity has been observed with malignant cells of pacients with B cell-derived CLL. In immunohistochemistry the antibody reacts with some tissue macrophages and carcinoma-expressed CEA. _x000D_ HLDA IV; WS Code M38 |
| Categories: | CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | The CD66 molecules are 180-200 kDa glycoproteins of carcinoembryonic antigen family. They are present on all blood granulocytes and some tissue macrophages, but are absent from other hematopoietic cells. The expression of CD66 increases significantly on granulocytes upon their activation. CD66a (BGP1, CEACAM1) and CD66d (CGM1, CEACAM3), as well as CEACAM2 and 4, are transmembrane proteins, whereas CD66c (CEAL, NCA, CEACAM6) and CD66e (CEA, CEACAM5), as well as CEACAM7 and 8, are anchored to the plasma membrane by C-terminal glycosylphosphatidylinositol (GPI) lipid moiety. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Teixeira AM, Fawcett J, Simmons DL, Watt SM: The N-domain of the biliary glycoprotein (BGP) adhesion molecule mediates homotypic binding: domain interactions and epitope analysis of BGPc. Blood. 1994 Jul 1;84(1):211-9., *Nagel G, Grunert F, Kuijpers TW, Watt SM, Thompson J, Zimmermann W: Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family. Eur J Biochem. 1993 May 15;214(1):27-35., *Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989)., *Tetteroo PA, Bos MJ, Visser FJ, von dem Borne AE: Neutrophil activation detected by monoclonal antibodies. J Immunol. 1986 May 1;136(9):3427-32._x000D_ _x000D_ _x000D_ |
| General references: | *Singer BB, Scheffrahn I, Kammerer R, Suttorp N, Ergun S, Slevogt H: Deregulation of the CEACAM expression pattern causes undifferentiated cell growth in human lung adenocarcinoma cells. PLoS One. 2010 Jan 18;5(1):e8747. |
| Related products: | - Mouse Monoclonal to CD69 - Mouse Monoclonal to CD66e / CEA - Mouse Monoclonal to CD68 |
| Shipping condition: | Room temperature |