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Data sheet of Mouse Monoclonal to CD44 / Pgp-1
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Porcine, Canine (Dog) |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD44 / Pgp-1
| Brand: | Exbio |
| Product no.: | 11-341-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD44 / Pgp-1 |
| Antigen: | CD44 |
| Clonality: | Monoclonal |
| Clone: | MEM-263 |
| Isotype: | IgG1 |
| Immunogen: | COS-7 cells (African Green Monkey). |
| Format: | purified |
| Specificity: | The antibody MEM-263 reacts with extracellular (N-terminal) domain of standard CD44 (Phagocyte glycoprotein 1), a 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes. _x000D_ HLDA III; WS Code T 155 |
| Categories: | CD Antigens & MHC (Veterinary), CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Leukocyte Typing III., McMichael A.J. et al. (Eds.), Oxford University Press (1987). |
| General references: | *Subramaniam V, Vincent IR, Gardner H, Chan E, Dhamko H, Jothy S: CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT _x000D_ phosphorylation. Exp Mol Pathol. 2007 Oct;83(2):207-15._x000D_ _x000D_ , *Subramaniam V, Gardner H, Jothy S: Soluble CD44 secretion contributes to the acquisition of aggressive tumor phenotype in human colon cancer cells. Exp Mol Pathol. 2007 Dec;83(3):341-6._x000D_ _x000D_ , *Liu J, Bi G, Wen P, Yang W, Ren X, Tang T, Xie C, Dong W, Jiang G. Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63._x000D_ , *Hollingsworth JW, Li Z, Brass DM, Garantziotis S, Timberlake SH, Kim A, Hossain I, Savani RC, Schwartz DA. CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease. Am J Respir Cell Mol Biol. 2007 Aug;37(2):248-53._x000D_ _x000D_ , *Vigetti D, Viola M, Karousou E, Rizzi M, Moretto P, Genasetti A, Clerici M, Hascall VC, De Luca G, Passi A: Hyaluronan-CD44-ERK1/2 regulate human aortic smooth muscle cell motility during aging. J Biol Chem. 2007 Dec 12 |
| Related products: | - Mouse Monoclonal to CD45R0 - Mouse Monoclonal to CD45 - Mouse Monoclonal to CD45R (bovine) |
| Shipping condition: | Room temperature |