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Data sheet of Mouse Monoclonal to CD41/CD61 (bovine)
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Bovine |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD41/CD61 (bovine)
| Brand: | Exbio |
| Product no.: | 11-356-C100 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD41/CD61 (bovine) |
| Antigen: | CD41/CD61 (bovine) |
| Clonality: | Monoclonal |
| Clone: | IVA30 |
| Isotype: | IgG2 |
| Immunogen: | Bovine trombocytes. |
| Format: | purified |
| Specificity: | The antibody IVA30 reacts with CD41/CD61 complex (bovine), one of the earliest markers of the megakaryocytic lineage. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41/CD61 is expressed only by platelets and megakaryocytes; the complex may be absent or strongly reduced in Glanzmann's thrombasthenia (GT). This antibody crossreacts with human platelets. |
| Categories: | CD Antigens & MHC (Veterinary) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD41 is a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD61 non-covalently associates with CD41. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Mateo A, Pintado CO, Perez de la Lastra J, Dusinsky R, Simon M, Naessens J, Llanes D: Ruminant cluster CD41/CD61. Vet Immunol Immunopathol. 1996 Aug;52(4):251-3. , *Naessens J, Howard CJ, Hopkins J: Nomenclature and characterization of leukocyte differentiation antigens in_x000D_ ruminants. Immunol Today. 1997 Aug;18(8):365-8., *Simon M, Dusinsky R, Horovska L, Bilka F, Hluchy S: Immunohistochemical reactivity of anti-platelet monoclonal antibodies. Vet Immunol Immunopathol. 1996 Aug;52(4):377-82. , *Mateo A, Perez de la Lastra J, Moreno A, Dusinsky R, Bilka F, Simon M, Horovska L, Llanes D: Biochemical characterization of antigens detected with anti-platelet monoclonal antibodies. Vet Immunol Immunopathol. 1996 Aug;52(4):363-70. , Other publications:, *Naessens J & Hopkins J: Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995. Vet Immunol Immunopathol 52:213-468 (1996). , III.Workshop on Ruminant Leukocyte Antigens: |
| Related products: | - Mouse Monoclonal to CD42a - Mouse Monoclonal to CD41a - Mouse Monoclonal to CD41b |
| Shipping condition: | Room temperature |