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Data sheet of Mouse Monoclonal to CD41 / Platelet GPIIb
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD41 / Platelet GPIIb
| Brand: | Exbio |
| Product no.: | 11-309-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD41 / Platelet GPIIb |
| Antigen: | CD41 |
| Clonality: | Monoclonal |
| Clone: | MEM-06 |
| Isotype: | IgG1 |
| Immunogen: | Leukocytes of patient suffering from LGL-type leukaemia. |
| Format: | purified |
| Specificity: | The antibody MEM-06 reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes. _x000D_ _x000D_ Workshop: HLDA 10 |
| Categories: | CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Komsa-Penkova R, Todinova SJ, Andreeva TD, Krumova SB, Taneva SG, Golemanov GM, Georgieva GA, Mihaylova NM, Tchorbanov PT: Alterations in platelet activity and elastic modulus of healthy subjects, carriers of G20210A polymorphism in the prothrombin gene. J Biomed Clin Res Volume 9 Number 1, 2016, *Pagani G, Pereira JPV, Stoldt VR, Beck A, Scharf RE, Gohlke H: The human platelet antigen-1b (Pro33) variant of αIIbβ3 allosterically shifts the dynamic conformational equilibrium of this integrin toward the active state. J Biol Chem. 2018 Mar 30;293(13):4830-4844., *Belizaire RM, Prakash PS, Richter JR, Robinson BR, Edwards MJ, Caldwell CC, Lentsch AB, Pritts TA: Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation. J Am Coll Surg. 2012 Apr;214(4):648-55 |
| General references: | *Debili N, Robin C, Schiavon V, Letestu R, Pflumio F, Mitjavila-Garcia MT, Coulombel L, Vainchenker W: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. Blood. 2001 Apr 1;97(7):2023-30._x000D_ _x000D_ _x000D_ , *Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T: CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Exp Hematol. 2007 Mar;35(3):490-499._x000D_ _x000D_ _x000D_ , *Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC: CD41 expression defines the onset of primitive and definitive hematopoiesis in_x000D_ the murine embryo. Development. 2003 Sep;130(18):4393-403._x000D_ _x000D_ _x000D_ , *Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W: Expression of CD41 on hematopoietic progenitors derived from embryonic_x000D_ hematopoietic cells. Development. 2002 Apr;129(8):2003-13._x000D_ _x000D_ _x000D_ |
| Related products: | - Mouse Monoclonal to CD41b - Mouse Monoclonal to CD41/CD61 (bovine) - Mouse Monoclonal to CD41a |
| Shipping condition: | Room temperature |