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Data sheet of Mouse Monoclonal to CD39
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD39
| Brand: | Exbio |
| Product no.: | 11-184-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD39 |
| Antigen: | CD39 |
| Clonality: | Monoclonal |
| Clone: | TU66 |
| Isotype: | IgG2b |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody TU66, also known as Tü66, recognizes CD39, a 78 kDa cell surface enzyme expressed by regulatory T cells, mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets._x000D_ HLDA IV; WS Code A54 |
| Categories: | CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), is a cell surface enzyme (with intracellular N- and C-terminus) which hydrolyzes extracellular ATP and ADP to AMP. Inhibition of its enzymatic activity may confer anticancer benefits. The formation of oligomers in the plasma membrane is essential for enzyme activity. It is expressed on Treg cells, and in other cell types, such as mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets. Hydrolysis of ATP and ADP inhibits inflammatory and thrombotic responses. In the nervous system, it regulates purinergic neurotransmission. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, Höpner S, Centonze D, Bernardi G, Dell'Acqua ML, Rossini PM, Battistini L, Rötzschke O, Falk K: Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood. 2007 Aug 15;110(4):1225-32., *Nikolova M, Carriere M, Jenabian MA, Limou S, Younas M, Kök A, Huë S, Seddiki N, Hulin A, Delaneau O, Schuitemaker H, Herbeck JT, Mullins JI, Muhtarova M, Bensussan A, Zagury JF, Lelievre JD, Lévy Y: CD39/adenosine pathway is involved in AIDS progression. PLoS Pathog. 2011 Jul;7(7):e1002110., *Wang YM, McRae JL, Robson SC, Cowan PJ, Zhang GY, Hu M, Polhill T, Wang Y, Zheng G, Wang Y, Lee VW, Unwin RJ, Harris DC, Dwyer KM, Alexander SI: Regulatory T cells participate in CD39-mediated protection from renal injury. Eur J Immunol. 2012 Sep;42(9):2441-51., Younas M, Hue S, Lacabaratz C, Guguin A, Wiedemann A, Surenaud M, Beq S, Croughs T, Lelièvre JD, Lévy Y: IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39/ATP axis. J Immunol. 2013 Sep 15;191(6):3161-8., Coppola A, Coppola L, dalla Mora L, Limongelli FM, Grassia A, Mastrolorenzo L, Gombos G, Lucivero G: Vigorous exercise acutely changes platelet and B-lymphocyte CD39 expression. J Appl Physiol (1985). 2005 Apr;98(4):1414-9., *Gadeock S, Tran JN, Georgiou JG, Jalilian I, Taylor RM, Wiley JS, Sluyter R: TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes. Biochim Biophys Acta. 2010 Nov;1798(11):2058-66. , *Jin Z, Teramoto N, Hayashi K, Liu YX, Jin G, Oka T, Takahashi K, Yoshino T, Akagi T: CD40 ligand stimulation inhibits the proliferation of mantle cell lymphoma lines. Anticancer Res. 2004 Mar-Apr;24(2B):691-7. |
| Related products: | - Mouse Monoclonal to CD4 / T4 - Mouse Monoclonal to CD4 - Mouse Monoclonal to CD4 (rat) |
| Shipping condition: | Room temperature |