Mouse Monoclonal to CD3 zeta (Phospho-Tyr111) View larger

Mouse Monoclonal to CD3 zeta (Phospho-Tyr111)

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Data sheet of Mouse Monoclonal to CD3 zeta (Phospho-Tyr111)

BrandExbio
Product typePrimary antibodies
ReactivityHuman, Mouse
ClonalityMonoclonal

More info about Mouse Monoclonal to CD3 zeta (Phospho-Tyr111)

Brand: Exbio
Product no.: 11-737-C025
Product type: Primary antibodies
Host species: Mouse
Product name: Mouse Monoclonal to CD3 zeta (Phospho-Tyr111)
Antigen: CD3 zeta (Phospho-Tyr111)
Clonality: Monoclonal
Clone: EM-55
Isotype: IgG1
Immunogen: BP1 (pTyr111/123) - KLH
Format: purified
Specificity: The mouse monoclonal antibody EM-55 recognizes phosphorylated tyrosine 111 of CD3 zeta chain (CD247), which is a component of TCR/CD3 complex expressed on T cells.
Categories: CD and Related Antigens & MHC (Rodent), CD and Related Antigens (Human)
Concentration: 1 mg/ml
Storage buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage / stability: Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Background: CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta (CD247). These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
Purity: > 95% (by SDS-PAGE)
Purification: Purified by protein-A affinity chromatography
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Shipping condition: Room temperature

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