Cart 0 Product Products (empty)
No products
To be determined Shipping
0,00 € Total
Prices are tax excluded
Product successfully added to your shopping cart
Quantity
Total
There are 0 items in your cart. There is 1 item in your cart.
Total products (tax excl.)
Total shipping (tax excl.) To be determined
Total (tax excl.)
Data sheet of Hamster Monoclonal to CD28 (mouse)
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Mouse |
| Clonality | Monoclonal |
More info about Hamster Monoclonal to CD28 (mouse)
| Brand: | Exbio |
| Product no.: | 12-597-C100 |
| Product type: | Primary antibodies |
| Host species: | Hamster |
| Product name: | Hamster Monoclonal to CD28 (mouse) |
| Antigen: | CD28 (mouse) |
| Clonality: | Monoclonal |
| Clone: | 37.51 |
| Isotype: | IgG |
| Immunogen: | Mouse T cell lymphoma EL-4 cells_x000D_ |
| Format: | low endotoxin |
| Specificity: | The Syrian hamster monoclonal antibody 37.51 reacts with extracellular domain of mouse CD28 costimulatory receptor, a 45 kDa homodimeric protein expressed by thymocytes, mature T cells and NK cells._x000D_ |
| Categories: | CD and Related Antigens & MHC (Rodent) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test. |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells._x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-G affinity chromatography |
| Product specific references: | *The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway. J Immunol. 2008 Apr 15;180(8):5506-11._x000D_ , *Rosenberger CM, Clark AE, Treuting PM, Johnson CD, Aderem A: ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2544-9._x000D_ , *Perchonock CE, Pajerowski AG, Nguyen C, Shapiro MJ, Shapiro VS: The related adaptors, adaptor in lymphocytes of unknown function X and_x000D_ Rlk/Itk-binding protein, have nonredundant functions in lymphocytes. J Immunol. 2007 Aug 1;179(3):1768-75._x000D_ , *Pua HH, Dzhagalov I, Chuck M, Mizushima N, He YW: A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med. 2007 Jan 22;204(1):25-31._x000D_ , *Perchonock CE, Fernando MC, Quinn WJ 3rd, Nguyen CT, Sun J, Shapiro MJ, Shapiro VS: Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX. Mol Cell Biol. 2006 Aug;26(16):6005-15._x000D_ , *Zhang N, He YW: The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. J Immunol. 2005 Jun 1;174(11):6967-73. _x000D_ , *Zhang N, He YW: An essential role for c-FLIP in the efficient development of mature T lymphocytes. J Exp Med. 2005 Aug 1;202(3):395-404._x000D_ , *Albert MH, Yu XZ, Martin PJ, Anasetti C: Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin. Blood. 2005 Feb 1;105(3):1355-61._x000D_ , *Gross JA, Callas E, Allison JP: Identification and distribution of the costimulatory receptor CD28 in the mouse. J Immunol. 1992 Jul 15;149(2):380-8._x000D_ , *Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP: CD28-mediated signalling co-stimulates murine T cells and prevents induction of_x000D_ anergy in T-cell clones. Nature. 1992 Apr 16;356(6370):607-9._x000D_ , *And many other._x000D_ |
| Related products: | - Hamster Monoclonal to CD79b (mouse) - Hamster Monoclonal to CD3 (mouse) - Hamster Monoclonal to CD3 zeta (CD247) |
| Shipping condition: | Room temperature |