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Data sheet of Mouse Monoclonal to CD193 / CCR3
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD193 / CCR3
| Brand: | Exbio |
| Product no.: | 11-161-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD193 / CCR3 |
| Antigen: | CD193 |
| Clonality: | Monoclonal |
| Clone: | 5E8 |
| Isotype: | IgG2b |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody 5E8 recognizes CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils. |
| Categories: | CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD193 / CCR3 is a G-protein coupled receptor for several chemokines, namely CCL11 (eotaxin), CCL26 (eotaxin-3), CCL7 (MCP-4), or CCL5 (RANTES). It is highly expressed on eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. CD193 is the key eosinophil chemokine receptor responsible for regulation of eosinophil migration and function. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Morshed M, Hlushchuk R, Simon D, Walls AF, Obata-Ninomiya K, Karasuyama H, Djonov V, Eggel A, Kaufmann T, Simon HU, Yousefi S: NADPH oxidase-independent formation of extracellular DNA traps by basophils. J Immunol. 2014 Jun 1;192(11):5314-23. |
| Related products: | - Mouse Monoclonal to CD1b - Mouse Monoclonal to CD195 / CCR5 - Mouse Monoclonal to CD1a |
| Shipping condition: | Room temperature |