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Data sheet of Mouse Monoclonal to CD13 / Aminopeptidase N
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Non-Human Primates |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD13 / Aminopeptidase N
| Brand: | Exbio |
| Product no.: | 11-396-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD13 / Aminopeptidase N |
| Antigen: | CD13 |
| Clonality: | Monoclonal |
| Clone: | WM15 |
| Isotype: | IgG1 |
| Immunogen: | Human AML cells |
| Format: | purified |
| Specificity: | The antibody WM15 recognises the human CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors. _x000D_ HLDA III; WS Code M 213 _x000D_ HLDA IV; WS Code M 44 _x000D_ HLDA IV; WS Code M 209 _x000D_ HLDA V; WS Code M MA191 |
| Categories: | CD Antigens & MHC (Veterinary), CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD13 (aminopeptidase N, APN) is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Favaloro EJ, Browning T, Facey D: CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated. Exp Hematol. 1993 Dec;21(13):1695-701. _x000D_ , *Bradstock KF, Favaloro EJ, Kabral A, Kerr A, Hughes WG, Musgrove E: Myeloid progenitor surface antigen identified by monoclonal antibody. Br J Haematol. 1985 Sep;61(1):11-20. _x000D_ , *Bradstock KF, Favaloro EJ, Kabral A, Kerr A, Hughes WG, Berndt MC, Musgrove E: Human myeloid differentiation antigens identified by monoclonal antibodies: expression on leukemic cells. Pathology. 1985 Jul;17(3):392-9. _x000D_ , *McCormack E, Mujic M, Osdal T, Bruserud O, Gjertsen BT: Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia. Blood. 2013 Feb 14;121(7):e34-42. doi: 10.1182/blood-2012-05-429555., *Leukocyte Typing III., McMichael A.J. et al. (Eds.), Oxford University Press (1987)., *Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989)., *Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995). |
| General references: | *Terauchi M, Kajiyama H, Shibata K, Ino K, Nawa A, Mizutani S, Kikkawa F. Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells. BMC Cancer. 2007 Jul 27;7:140._x000D_ _x000D_ _x000D_ , *Petrovic N, Schacke W, Gahagan JR, O'Conor CA, Winnicka B, Conway RE, Mina-Osorio_x000D_ P, Shapiro LH. CD13/APN regulates endothelial invasion and filopodia formation. Blood. 2007 Jul 1;110(1):142-50._x000D_ _x000D_ , *Tokuhara T, Hattori N, Ishida H, Hirai T, Higashiyama M, Kodama K, Miyake M. Clinical significance of aminopeptidase N in non-small cell lung cancer. Clin Cancer Res. 2006 Jul 1;12(13):3971-8._x000D_ |
| Related products: | - Mouse Monoclonal to CD135 - Mouse Monoclonal to CD133 - Mouse Monoclonal to CD134 |
| Shipping condition: | Room temperature |