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Data sheet of Mouse Monoclonal to CD101
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD101
| Brand: | Exbio |
| Product no.: | 11-778-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD101 |
| Antigen: | CD101 |
| Clonality: | Monoclonal |
| Clone: | BB27 |
| Isotype: | IgG1 |
| Immunogen: | Human thymic clone B12 |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody BB27 recognizes CD101, a 140 kDa disulfide-bonded homodimeric protein expressed on activated T cells, and some ther cell types, such as granulocytes and cells of the monocyte/macropgage lineage._x000D_ _x000D_ HLDA V; WS Code T040 |
| Categories: | CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD101 is a type I transmembrane glycoprotein, which forms disulfide-linked homodimers. It is expressed on activated T cells, as well as on granulocytes, monocytes, dendritic cells or mucosal T cells. It plays a major role in the activation of T cells by skin dendritic cells. Function of CD101 has not been fully elucidated, but in mice its knock-out results in liver autoimmune disease induced by Novosphingobium aromaticivorans. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Grassi F, Dezutter-Dambuyant C, McIlroy D, Jacquet C, Yoneda K, Imamura S, Boumsell L, Schmitt D, Autran B, Debré P, Hosmalin A: Monocyte-derived dendritic cells have a phenotype comparable to that of dermal dendritic cells and display ultrastructural granules distinct from Birbeck granules. J Leukoc Biol. 1998 Oct;64(4):484-93., *Bagot M, Martinel I, Charue D, Boulland ML, Wechsler J, Bensussan A, Boumsell L: Functional role of CD101 on skin dendritic cells. Adv Exp Med Biol. 1997;417:227-32., Bagot M, Martinel I, Charue D, Weill F, Boulland ML, Wechsler J, Freeman GJ, Bensussan A, Boumsell L: CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation. Tissue Antigens. 1997 Nov;50(5):439-48., *Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995). |
| Related products: | - Mouse Monoclonal to CD105 / Endoglin - Mouse Monoclonal to CD102 / ICAM-2 - Mouse Monoclonal to CD103 / Integrin alpha E |
| Shipping condition: | Room temperature |