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Data sheet of Mouse Monoclonal to CD10 / CALLA
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Other not tested, Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD10 / CALLA
| Brand: | Exbio |
| Product no.: | 11-413-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD10 / CALLA |
| Antigen: | CD10 |
| Clonality: | Monoclonal |
| Clone: | LT10 |
| Isotype: | IgG1 |
| Immunogen: | mouse NALM-6 leukemia pre-B cell line (tissue/cell preparation) |
| Format: | purified |
| Specificity: | The antibody LT10 reacts with CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein. |
| Categories: | CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD10 (neutral endopeptidase – NEP, common acute lymphocytic leukemia antigen – CALLA, membrane metallo-endopeptidase – MME, enkefalinase) is a 100-kDa cell surface zinc metalloprotease cleaving peptide bonds on the N-terminus of hydrophobic amino acids and inactivating multiple physiologically active peptids. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for diagnostics of many carcinomas. CD10 is also a differentiation antigen for early B-lymphoid progenitors in the B-cell differentiation pathway and has a key role in regulation of growth, differentiation and signal transduction of many cellular systems. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by precipitation and chromatography |
| Product specific references: | *Leukocyte Typing VII., Mason D. et al. (Eds.), Oxford University Press (2002). |
| General references: | *Dall'Era MA, True LD, Siegel AF, Porter MP, Sherertz TM, Liu AY: Differential expression of CD10 in prostate cancer and its clinical implication. BMC Urol. 2007 Mar 2;7:3., *Braham H, Trimeche M, Ziadi S, Mestiri S, Mokni M, Amara K, Hachana M, Sriha B, Korbi S: CD10 expression by fusiform stromal cells in nasopharyngeal carcinoma correlates with tumor progression. Virchows Arch. 2006 Aug;449(2):220-4., *Yada K, Kashima K, Daa T, Kitano S, Fujiwara S, Yokoyama S: Expression of CD10 in basal cell carcinoma._x000D_ Am J Dermatopathol. 2004 Dec;26(6):463-71., *Suzuki T, Ino K, Kikkawa F, Uehara C, Kajiyama H, Shibata K, Mizutani S: Neutral endopeptidase/CD10 expression during phorbol ester-induced_x000D_ differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway. Placenta. 2002 Jul;23(6):475-82._x000D_ |
| Related products: | - Mouse Monoclonal to CD103 / Integrin alpha E - Mouse Monoclonal to CD101 - Mouse Monoclonal to CD102 / ICAM-2 |
| Shipping condition: | Room temperature |