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Data sheet of Mouse Monoclonal to Brg1
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Other not determined |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Brg1
| Brand: | Exbio |
| Product no.: | 11-541-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Brg1 |
| Antigen: | Brg1 |
| Clonality: | Monoclonal |
| Clone: | BRG-01 |
| Isotype: | IgG2a |
| Immunogen: | Bacterially produced GST-fused protein representing 242 C-terminal amino acids of human Brg1. _x000D_ |
| Format: | purified |
| Specificity: | The antibody BRG-01 recognizes an epitope within C-terminal part of human Brg1, a 205 kDa catalytic subunit of SWI2/SNF2-family chromatin-remodeling complexes._x000D_ |
| Categories: | Transcription Regulation & Nuclear Proteins, Transcription Regulation & Nuclear Proteins (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression. _x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| General references: | *Ooi L, Belyaev ND, Miyake K, Wood IC, Buckley NJ:_x000D_ BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates_x000D_ REST-mediated repression._x000D_ J Biol Chem. 2006 Dec 22;281(51):38974-80., *Griffin CT, Brennan J, Magnuson T: The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development. 2008 Feb;135(3):493-500., *Napolitano MA, Cipollaro M, Cascino A, Melone MA, Giordano A, Galderisi U: Brg1 chromatin remodeling factor is involved in cell growth arrest, apoptosis and senescence of rat mesenchymal stem cells. J Cell Sci. 2007 Aug 15;120(Pt 16):2904-11., *Eroglu B, Wang G, Tu N, Sun X, Mivechi NF: Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish._x000D_ Dev Dyn. 2006 Oct;235(10):2722-35._x000D_ , *Trotter KW, Archer TK.: The BRG1 transcriptional coregulator. Nucl Recept Signal. 2008 Feb 1;6:e004. |
| Related products: | - Mouse Monoclonal to CD102 / ICAM-2 - Mouse Monoclonal to CD10 / CALLA - Mouse Monoclonal to CD101 |
| Shipping condition: | Room temperature |