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Data sheet of Mouse Monoclonal to betaIII-tubulin
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Broad species reactivity |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to betaIII-tubulin
| Brand: | Exbio |
| Product no.: | 11-264-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to betaIII-tubulin |
| Antigen: | betaIII-tubulin |
| Clonality: | Monoclonal |
| Clone: | TU-20 |
| Isotype: | IgG1 |
| Immunogen: | Peptide (C) 441-448 coupled to maleimide-activated keyhole limpet hemocyanin via cysteine added to the N-terminus of the neuron-specific peptide. |
| Format: | purified |
| Specificity: | The antibody TU-20 recognizes C-terminal peptide sequence ESESQGPK (aa 441-448) of neuron-specific human betaIII-tubulin. |
| Categories: | Neurobiology (Veterinary), Neurobiology (Rodent), Neurobiology (Human), Cytoskeleton: Tubulin System (Veterinary), Cytoskeleton: Tubulin System (Rodent), Cytoskeleton: Tubulin System (Human), Cytoskeleton: Microtubular System |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | The betaIII-tubulin isoform is present dominantly in cells of neuronal origin and it is one of the earliest markers of neuronal differentiation. It is regarded as a specific probe for the cells of neuronal origin as well as for the tumours originating from these cells. The betaIII-tubulin is most abundant in cells of neuronal origin, but was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by precipitation methods |
| Product specific references: | *Theodorou E, Dalembert G, Heffelfinger C, White E, Weissman S, Corcoran L, Snyder M: A high throughput embryonic stem cell screen identifies Oct-2 as a bifunctional regulator of neuronal differentiation. Genes Dev. 2009 Mar 1;23(5):575-88._x000D_ _x000D_ _x000D_ , *Kukharskyy V, Sulimenko V, Macůrek L, Sulimenko T, Dráberová E, Dráber P: Complexes of gamma-tubulin with nonreceptor protein tyrosine kinases Src and Fyn _x000D_ in differentiating P19 embryonal carcinoma cells._x000D_ Exp Cell Res. 2004 Aug 1;298(1):218-28., *Dráberová E, Sulimenko V, Vinopal S, Sulimenko T, Sládková V, D'Agostino L, Sobol M, Hozák P, Křen L, Katsetos CD, Dráber P: Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function. FASEB J. 2017 May;31(5):1828-1846., *Draberova E, Lukas Z, Ivanyi D, Viklicky V, Draber P: Expression of class III beta-tubulin in normal and neoplastic human tissues. Histochem Cell Biol. 1998 Mar;109(3):231-9. _x000D_ , *Jirásek T, Cipro S, Musilová A, Kubecová M, Mandys V: Expression of class III beta-tubulin in colorectal carcinomas: an immunohistochemical study using TU-20 & TuJ-1 antibody. Indian J Med Res. 2009 Jan;129(1):89-94._x000D_ _x000D_ _x000D_ , *Katsetos CD, Draberova E, Smejkalova B, Reddy G, Bertrand L, de Chadarévian J-P, Legido A, Nissanov J, Baas PW, Draber P: Class III β-Tubulin and γ-Tubulin are Co-expressed and form Complexes in Human Glioblastoma Cells. Neurochem Res (2007) 32:1387-1398., *Jirasek T, Pisarikova E, Viklicky V, Mandys V: Expression of class III beta-tubulin in malignant epithelial tumours: an_x000D_ immunohistochemical study using TU-20 and TuJ-1 antibodies. Folia Histochem Cytobiol. 2007;45(1):41-5. _x000D_ , *Peknicova J, Kubatova A, Sulimenko V, Draberova E, Viklicky V, Hozak P, Draber P: Differential subcellular distribution of tubulin epitopes in boar spermatozoa:_x000D_ recognition of class III beta-tubulin epitope in sperm tail._x000D_ Biol Reprod. 2001 Sep;65(3):672-9. _x000D_ |
| Related products: | - Mouse Monoclonal to Blood Group A - Mouse Monoclonal to beta-tubulin - Mouse Monoclonal to beta-tubulin / TUBB |
| Shipping condition: | Room temperature |