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Data sheet of Mouse Monoclonal to Basic Cytokeratins
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Non-Human Primates, Mouse, Rat, Bovine, Rabbit, Chicken |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Basic Cytokeratins
| Brand: | Exbio |
| Product no.: | 11-769-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Basic Cytokeratins |
| Antigen: | Basic Cytokeratins |
| Clonality: | Monoclonal |
| Clone: | AE3 |
| Isotype: | IgG1 |
| Immunogen: | Human epidermal keratins |
| Format: | purified |
| Specificity: | Mouse monoclonal antibody AE3 recognizes all basic type cytokeratins, namely K1-K8 (58-67 kDa). This antibody reacts with all layers of epidermis (basal layer and above) and is an excellent marker for distinguishing carcinomas from non-epithelial tumours. |
| Categories: | Cytoskeleton: Intermediate Filaments (Veterinary), Cytoskeleton: Intermediate Filaments (Rodent), Cytoskeleton: Intermediate Filaments (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Cytokeratins are a subfamily of intermediate filaments and are characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Hunt RC, Davis AA: Altered expression of keratin and vimentin in human retinal pigment epithelial cells in vivo and in vitro. J Cell Physiol. 1990 Nov;145(2):187-99., *Woodcock-Mitchell J, Eichner R, Nelson WG, Sun TT: Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol. 1982 Nov;95(2 Pt 1):580-8., *Zhang B, Chen Y, Han Z, Ris H, Zhai Z: The role of keratin filaments during nuclear envelope reassembly in Xenopus egg extracts. FEBS Lett. 1998 May 22;428(1-2):52-6., *Yeh IT, Miller AR: Staining of sentinel node reticulum cells with cytokeratin antibody AE3. Arch Pathol Lab Med. 2002 Mar;126(3):248-9., *Listrom MB, Dalton LW: Comparison of keratin monoclonal antibodies MAK-6, AE1:AE3, and CAM-5.2. Am J Clin Pathol. 1987 Sep;88(3):297-301. |
| Related products: | - Mouse Monoclonal to beta Endorphin - Mouse Monoclonal to Bcl2 - Mouse Monoclonal to Benzo[a]pyrene |
| Shipping condition: | Room temperature |