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Data sheet of Mouse Monoclonal to AGR2+AGR3
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Other species Not tested |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to AGR2+AGR3
| Brand: | Exbio |
| Product no.: | 11-562-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to AGR2+AGR3 |
| Antigen: | AGR2+AGR3 |
| Clonality: | Monoclonal |
| Clone: | AGR3.4 |
| Isotype: | IgG1 |
| Immunogen: | Purified human AGR3 protein_x000D_ |
| Format: | purified |
| Specificity: | The antibody AGR3.4 recognizes the PLMII epitope of AGR3 (AG3) and AGR2 (AG2) proteins (19-20 kDa); secreted cytoplasmic proteins which can serve as markers of carcinogenesis. _x000D_ |
| Categories: | Serum & Plasma Proteins (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide. |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | AGR2 (Anterior Gradient 2), also known as AG2 (hAG-2, HAG2 in human), or GOB-4, and AGR3 (Anterior Gradient 3), also known as AG3 (hAG-3, HAG3 in human), or BCMP11, are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours; AGR2 was reported also as a marker of other carcinomas. Xenopus homolog of these proteins is associated with anteroposterior fate determination during early development._x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| General references: | *Fletcher GC, Patel S, Tyson K, Adam PJ, Schenker M, Loader JA, Daviet L, Legrain P, Parekh R, Harris AL, Terrett JA: hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with_x000D_ metastasis gene C4.4a and dystroglycan. Br J Cancer. 2003 Feb 24;88(4):579-85._x000D_ , *Persson S, Rosenquist M, Knoblach B, Khosravi-Far R, Sommarin M, Michalak M: Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family. Mol Phylogenet Evol. 2005 Sep;36(3):734-40._x000D_ , *Ramachandran V, Arumugam T, Wang H, Logsdon CD: Anterior gradient 2 is expressed and secreted during the development of_x000D_ pancreatic cancer and promotes cancer cell survival. Cancer Res. 2008 Oct 1;68(19):7811-8._x000D_ , *Zweitzig DR, Smirnov DA, Connelly MC, Terstappen LW, O'Hara SM, Moran E: Physiological stress induces the metastasis marker AGR2 in breast cancer cells. Mol Cell Biochem. 2007 Dec;306(1-2):255-60._x000D_ , *Zhang JS, Gong A, Cheville JC, Smith DI, Young CY: AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. Genes Chromosomes Cancer. 2005 Jul;43(3):249-59._x000D_ |
| Related products: | - Mouse Monoclonal to Albumin - Mouse Monoclonal to AGR3 - Mouse Monoclonal to AHNAK1 |
| Shipping condition: | Room temperature |