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Data sheet of Mouse Monoclonal to Acidic Cytokeratins
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Non-Human Primates, Mouse, Rat, Canine (Dog), Feline (Cat), Rabbit, Chicken |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to Acidic Cytokeratins
| Brand: | Exbio |
| Product no.: | 11-768-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to Acidic Cytokeratins |
| Antigen: | Acidic Cytokeratins |
| Clonality: | Monoclonal |
| Clone: | AE1 |
| Isotype: | IgG1 |
| Immunogen: | Human epidermal keratins |
| Format: | purified |
| Specificity: | Mouse monoclonal antibody AE1 recognizes acidic type cytokeratins, namely K10, 14, 15, 16, 19 (40-56 Kda). This antibody stains well the basal layer of epidermis and most epithelia. |
| Categories: | Cytoskeleton: Intermediate Filaments (Veterinary), Cytoskeleton: Intermediate Filaments (Rodent), Cytoskeleton: Intermediate Filaments (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Listrom MB, Dalton LW: Comparison of keratin monoclonal antibodies MAK-6, AE1:AE3, and CAM-5.2. Am J Clin Pathol. 1987 Sep;88(3):297-301., *Hunt RC, Davis AA: Altered expression of keratin and vimentin in human retinal pigment epithelial cells in vivo and in vitro. J Cell Physiol. 1990 Nov;145(2):187-99., *Ansai SI, Katagata Y, Yoshikawa KI, Hozumi Y, Aso K: Keratin specificity analyses of eight anti-keratin monoclonal antibodies, and their immunostaining patterns in normal skin using formalin-fixed and paraffin-embedded tissue specimens. Arch Dermatol Res. 1993;285(1-2):6-12., *Woodcock-Mitchell J, Eichner R, Nelson WG, Sun TT: Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol. 1982 Nov;95(2 Pt 1):580-8. |
| Related products: | - Mouse Monoclonal to AGPS - Mouse Monoclonal to Acrosin (Porcine) - Mouse Monoclonal to Actin (muscle) |
| Shipping condition: | Room temperature |